Jim Al-Khalili talks T cells, our immune response and Long Covid with Prof Danny Altmann.  Danny Altmann joined ‘team T cells’ in his twenties and has been studying how these killer operate ever since. How do they know which cells to search and destroy?  
The T cell wing of our immune response is highly targeted and incredibly clever, on a par with the most sophisticated military intelligence operation and in recent decades there have been dramatic advances in our understanding of how it all works .  Danny tells Jim how he came to study our immune response to all sorts of pathogens, from anthrax to zika, why he spends every morning from 5 to 6am in the bath reading 19th century classics and why he’s determined to try and understand Long Covid.
Producer: Anna Buckley

Danny Altmann on how T cells fight disease

Professor Jim Al-Khalili talks to leading scientists about their life and work, finding out what inspires and motivates them and asking what their discoveries might do for us in the future

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What is the universe made of? Where does space dust come from? 
And how exactly might one go about putting on a one-man-show about Sir Isaac Newton?  These are all questions that Mike Edmunds, Emeritus Professor of Astrophysics at Cardiff University and President of the Royal Astronomical Society (RAS), has tackled during his distinguished career. And although physics is his first love, Mike is fascinated by an array of scientific disciplines - with achievements ranging from interpreting the spread of chemical elements in the Universe, to decoding the world’s oldest-known astronomical artefact.  Recording in front of an audience at the RAS in London, Professor Jim Al-Khalili talks to Mike about his life, work and inspirations. 
And who knows, Sir Isaac might even make an appearance… Produced by Lucy Taylor.

Mike Edmunds on decoding galaxies and ancient astronomical artefacts

With 86 billion nerve cells joined together in a network of 100 trillion connections, the human brain is the most complex system in the known universe.  Dr. Hannah Critchlow is an internationally acclaimed neuroscientist who has spent her career demystifying and explaining the brain to audiences around the world. Through her writing, broadcasting and lectures to audiences – whether in schools, festivals or online – she has become one of the public faces of neuroscience. She tells Professor Jim Al-Khalili that her desire to understand the  brain began when she spent a year after school as a nursing assistant in a psychiatric hospital. The experience of working with young patients - many the same age as her - made her ask what it is within each individual brain which determines people’s very different life trajectories.  In her books she’s explored the idea that much of our character and behaviour is hard-wired into us before we’re even born. And most recently she’s considered collective intelligence, asking how we can bring all our individual brains together and harness their power in one ‘super brain’. And we get to hear Jim’s own mind at work as Hannah attaches electrodes to his head and turns his brain waves into sound. Producer: Jeremy Grange

Hannah Critchlow on the connected brain

The reputation of the nuclear industry has had highs and lows during the career of Dr Fiona Rayment, the President of the Nuclear Institute. But nowadays the role of nuclear science and engineering has become more widely accepted in the quest for carbon net zero. Growing up in Hamilton, Scotland during a time of energy insecurity, Fiona was determined to understand more about why her school lacked the energy to heat up all of the classrooms or why there were power cuts causing her to have to do her homework by candlelight - and in nuclear she knew there was a possible solution.  But it’s not just in clean energy that Fiona has spent her career, she’s also been involved in investigating how nuclear science can be used in treating cancer and space travel, as well as promoting gender diversity in the nuclear industry.  Speaking to Professor Jim Al-Khalili, Fiona discusses how she’s always tried to keep close to the science during her career in order to keep her ‘spark’! Produced by Jonathan Blackwell

Fiona Rayment on the applications of nuclear for net zero and beyond

We are fascinated by dinosaurs. From blockbuster hits to bestselling video games, skeleton exhibitions to cuddly plushies, the creatures that once roamed the planet have fully captured our imagination, giving us a portal to a completely alternative Earth. And it’s likely new species are still out there, waiting to be found...   Dr Nick Longrich is a palaeontologist and senior lecturer at the University of Bath, and he studies the dinosaur bones that many have overlooked. By rummaging through the back rooms of museums, he finds traces of never-before-described dinosaurs and goes on the hunt for other specimens to confirm or deny his hunch. Through these adventures, he’s discovered over a dozen new species, painting a more detailed picture of our prehistoric world.  Nick is also fascinated by rare ‘one in a million year’ events – like asteroid collisions or mega volcanic eruptions – and investigates how the event that wiped out the dinosaurs created the world we live in today. From an Island off the coast of Alaska, Jim Al-Khalili discovers how Nicks early immersion in nature has trained his brain to spot the subtle differences in the world around us that many would overlook.  Produced by Julia Ravey.

Nick Longrich on discovering new dinosaurs from overlooked bones

Dr Sheila Willis is a forensic scientist who was Director General of Forensic Science Ireland for many years.  She has spent her life using science to help solve cases, working on crime scenes and then analysing material in the lab, and presenting scientific evidence in court. It’s a complicated business. Forensic science relies on powerful technology, such as DNA analysis, but it cannot be that alone - it’s also about human judgement, logical reasoning and asking the right questions.  It is these fundamentals of forensic science that Sheila has fought for through her long career and what she fears may be becoming lost from the field now. We find out what happens when the two very different worlds of science and the law clash in the courtroom. How to walk the line of presenting scientific evidence where there is pressure to be definitive where often science cannot be - and what this part of the job has in common with food packaging. And what makes a good forensic scientist?  We’ll turn the studio at London’s Broadcasting House into a live crime scene to see if host Professor Jim Al-Khalili would be any good as a forensic investigator… Produced by Gerry Holt

Danny Altmann on how T cells fight disease

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