Ground Truths

Ground Truths episodes:

• 05.28.2024

  Venki Ramakrishnan: The New Science of Aging

  Professor Venki Ramakrishnan, a Nobel laureate for his work on unraveling the structure of function of the ribosome, has written a new book WHY WE DIE which is outstanding. Among many posts and recognitions for his extraordinary work in molecular...

  
• 05.20.2024

  Svetlana Blitshteyn: On the Front Line With Long Covid and POTS

  After finishing her training in neurology at Mayo Clinic, Dr. Svetlana Blitshteyn started a Dysautonomia Clinic in 2009. Little did she know what was in store many years later when Covid hit! Ground Truths podcasts are on Apple and Spotify....

  
• 05.12.2024

  Kate Crawford: A Leading Scholar and Conscience for A.I.

  “We haven't invested this much money into an infrastructure like this really until you go back to the pyramids”—Kate Crawford Transcript with links to audio and external links. Ground Truths podcasts are on Apple and Spotify. The video interviews...

  
• 05.04.2024

  Akiko Iwasaki: The Immunology of Covid and the Future

  If there’s one person you’d want to talk to about immunology, the immune system and Covid, holes in our knowledge base about the complex immune system, and where the field is headed, it would be Professor Iwasaki. And add to...

  
• 04.28.2024

  Aviv Regev: The Revolution in Digital Biology

  “Where do I think the next amazing revolution is going to come? … There’s no question that digital biology is going to be it. For the very first time in our history, in human history, biology has the opportunity...

  
• 04.14.2024

  Jennifer Doudna: The Exciting Future of Genome Editing

  Professor Doudna was awarded the 2020 Nobel Prize in Chemistry with Professor Emmanuelle Charpentier for their pioneering work in CRISPR genome editing. The first genome editing therapy (Casgevy) was just FDA approved, only a decade after the CRISPR-Cas9 editing system...

  
• 04.06.2024

  Daniel Drucker: Illuminating the GLP-1 Drug's Break Out

  Note: This podcast is a companion to the Ground Truths newsletter “A Big Week for GLP-1 Drugs” Eric Topol (00:06): It is Eric Topol with Ground Truths, and with me today is Dr. Daniel Drucker from the University of Toronto,...

  
• 03.29.2024

  Sid Mukherjee: On A.I., Longevity and Being A Digital Human

  Siddhartha Mukherjee is a Professor at Columbia University, oncologist, and extraordinary author of Emperor of All Maladies (which was awarded a Pulitzer Prize), The Gene, and The Song of the Cell, along with outstanding pieces in the New Yorker. He...

  
• 03.17.2024

  Holden Thorp: Straight Talk from the Editor-in-Chief of the Science family of journals

  There was so much to talk about—this is the longest Ground Truths podcast yet. Hope you’ll find it as thought-provoking as I did! Transcript, with audio and external links, edited by Jessica Nguyen, Producer for Ground Truths Video and audio...

  
• 03.10.2024

  Daphne Koller: The Convergence of A.I. and Digital Biology

  Transcript Eric Topol (00:06): Well, hello, this is Eric Topol with Ground Truths and I am absolutely thrilled to welcome Daphne Koller, the founder and CEO of insitro, and a person who I've been wanting to meet for some...

  
• 03.03.2024

  Coleen Murphy: The Science of Aging and Longevity

  “A few years ago, I might have chuckled at the naiveté of this question, but now it's not so crazy to think that we will be able to take some sort of medicine to extend our healthy lifespans in the...

  
• 02.25.2024

  Michelle Monje: The Brain in Long Covid and Cancer

  Transcript with audio and relevant external links, recorded on 6 Feb 2024 Eric Topol (00:05): Hello, this is Eric Topol with Ground Truths, and I have a remarkable guest with me today, Professor Michelle Monje, who is from...

  
• 02.13.2024

  Jim Collins: Discovery of the First New Structural Class of Antibiotics in Decades, Using A.I.

  Jim Collins is one of the leading biomedical engineers in the world. He’s been elected to all 3 National Academies (Engineering, Science, and Medicine) and is one of the founders of the field of synthetic biology. In this conversation, we...

  
• 02.02.2024

  Katalin Karikó: The unimaginable, obstacle-laden, multi-decade journey to discover the mRNA platform and win the 2023 Nobel Prize

  “The history of science, it turns out, is filled with stories of very smart people laughing at good ideas.”—Katalin Karikó ...

  
• 01.25.2024

  Jonathan Howard, author of We Want Them Infected

  Jonathan Howard is a neurologist and psychiatrist who practices at NYU-Bellevue and posts frequently on Science Based Medicine. Transcript, unedited, with links to audio Eric Topol (00:05): Well, hello, Eric Topol with Ground Truths and I'm really pleased...

  
• 01.18.2024

  An exhilarating conversation with Azeem Azhar on medical A.I., science of aging, genome editing and the GLP-1 drugs

  is an award-wining entrepreneur and innovator in technology, especially A.I., a member of the editorial board of Harvard Business Review, and an outstanding communicator which makes him a frequent media guest and often featured in The Economist, WSJ, and Financial...

  
• 01.13.2024

  Liv Boeree: On Competition, Moloch Traps, and the A.I. Arms Race

  A snippet of our conversation below Transcript of our conversation 8 January 2023, edited for accuracy, with external links Eric Topol It’s a pleasure for me to have Liv Boeree as our Ground Truths podcast guest today. I...

  
• 12.26.2023

  Tony Wyss-Coray: The Science of Aging

  The science to advance our understanding of the aging process—and to potentially slow it down—has made important strides. One of the leading scientists responsible for this work is Professor Tony Wyss-Coray, whose work has particularly focused on brain aging...

  
• 12.10.2023

  David Liu: A Master Class on the Future of Genome Editing

  David Liu is an gifted molecular biologist and chemist who has pioneered major refinements in how we are and will be doing genome editing in the future, validating the methods in multiple experimental models, and establishing multiple companies to accelerate...

  
• 12.08.2023

  Geoffrey Hinton: Large Language Models in Medicine. They Understand and Have Empathy

  This is one of the most enthralling and fun interviews I’ve ever done (in 2 decades of doing them) and I hope that you’ll find it stimulating and provocative. If you did, please share with your network. And thanks for...

  
• 11.21.2023

  Andrew Ng: On OpenAI's stormy times, AI regulation, education, and where we are headed for healthcare and beyond

  “A.I. is not the problem; it’s the solution.”—Andrew Ng at TED, 17 October 2023 Recorded 21 November 2023 Transcript with relevant links and links to audio file Eric Topol (00:00): Hello, it's Eric Topol with Ground Truths, and I'm...

  
• 10.24.2023

  The Science Behind Food and Dangers of Ultra-Processed, Artificial, Non-Food with Dr. Chris Van Tulleken

  If you care about what you eat, you won’t want to miss this conversation! Chris Van Tulleken is an infectious disease physician-scientist in the UK’s National Health Service who has written a deeply researched masterpiece book on food—ULTRA-PROCESSED PEOPLE. It’s...

  
• 10.19.2023

  Peter Attia: Our conversation about his hit book OUTLIVE, Medicine 3.0, promoting healthspan, GLP-1 drugs and more

  In July, I reviewed Peter’s Outlive book here in Ground Truths and hoped I’d be able to interview him about my concerns. Here’s that conversation, recorded October 16th. I hope you’ll find it informative and stimulating! The AI...

  
• 10.12.2023

  On Genome Editing With Fyodor Urnov, A Pioneer

  Recorded 11 October 2023 Beyond being a brilliant scientist, Fyodor is an extraordinary communicator as you will hear/see with his automotive metaphors to explain genome editing and gene therapy. His recent NY Times oped (link below) confronts the critical issues...

  
• 09.19.2023

  Straight Talk with Peter Hotez

  Dr. Peter Hotez is a veritable force. He has been the tip of the spear among physicians and scientists for taking on anti-science and has put himself and his family at serious risk.Along with Dr. Maria Bottazzi, he developed...

  
• 09.11.2023

  Ziyad Al-Aly: Illuminating Long Covid

  Few, if any, physician researchers have done more to understand the long-term impact of Covid than Dr. Ziyad Al-Aly, a professor, nephrologist, and epidemiologist along with his team at Washington University, St. Louis. Here is the transcript (with links...

  
• 08.19.2023

  Straight talk with Magdalena Skipper, the Editor-in-Chief at Nature

  Eric Topol (00:00): Hello, this is Eric Topol, and I'm thrilled to have a chance to have a conversation with Magdalena Skipper, who is the Editor-in-Chief of Nature. And a historic note. Back in 2018, she became...

  
• 08.11.2023

  John Halamka: How Mayo Clinic is Transforming Healthcare with A.I.

  Transcript Eric Topol (00:00): This is a real great opportunity to speak to one of the most impressive medical informaticists and leaders in AI in the United States and worldwide. Dr. John Halamka, just by way of background,...

  
• 08.04.2023

  Melanie Mitchell: Straight Talk on A.I. Large Language Models

  Transcript with Links Eric Topol (00:00): This is Eric Topol, and I'm so excited to have the chance to speak to Melanie Mitchell. Melanie is the Davis Professor of Complexity at the Santa Fe Institute in New Mexico. And...

  
• 06.21.2023

  Al Gore: The Intersection of A.I. and Climate Change

  Transcript with some hyperlinks Eric Topol (00:00): Hello, Eric Topol here. And what a privilege to have as my guest Al Gore, as we discuss things that are considered existential threats. And that includes not just climate change but...

  
• 06.06.2023

  Hannah Davis: A 360° on Long Covid

  TRANSCRIPT Eric Topol (00:00): Hello, this is Eric Topol, and it's really a delight for me to welcome Hannah Davis who was the primary author of our recent review on Long Covid and is a co-founder of the Patient-Led Research...

  
• 05.22.2023

  Peter Lee and the Impact of GPT-4 + Large Language AI Models in Medicine

  Link to the book: The AI Revolution in Medicine Link to my review of the book Link to the Sparks of Artificial General Intelligence preprint we discussed Link to Peter’s paper on GPT-4 in NEJM Transcript (with...

  
• 05.05.2023

  Straight talk with Michael Osterholm

  Transcript Eric (00:00): Okay. Hello, this is Eric Topol and this is a rare privilege for me to interview my favorite epidemiologist, Dr. Michael Osterholm. He is the Regents Professor of the University of Minnesota. He's director of CIDRAP,...