Monica Bertagnolli went from a childhood on a cattle ranch to a career as a surgeon to a top post in the Biden administration. As director of the National Institutes of Health, she’s working to improve the way we find new treatments — despite regulatory constraints and tight budgets.

129. How to Fix Medical Research

Freakonomics co-author Steve Levitt tracks down other high achievers for surprising, revealing conversations about their lives and obsessions. Join Levitt as he goes through the most interesting midlife crisis you’ve ever heard — and learn how a renegade sheriff is transforming Chicago's jail, how a biologist is finding the secrets of evolution in the Arctic tundra, and how a trivia champion memorized 160,000 flashcards.

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Society & Culture

Personal Journals

History

Philosophy

Places & Travel

The economist Joseph Stiglitz has devoted his life to exposing the limits of markets. He tells Steve about winning an argument with fellow Nobel laureate Milton Friedman, why small governments don’t lead to more freedom, and why he’s not afraid to be an advocate.

130. Is Our Concept of Freedom All Wrong?

Nobel laureate, bestselling author, and groundbreaking psychologist Daniel Kahneman died in March. In 2021 he talked with Steve Levitt — his friend and former business partner — about his book "Noise: A Flaw in Human Judgment" (cowritten with Olivier Sibony and Cass Sunstein) and much more.

EXTRA: Remembering Daniel Kahneman

Google researcher Blaise Agüera y Arcas spends his work days developing artificial intelligence models and his free time conducting surveys for fun. He tells Steve how he designed an algorithm for the U.S. Navy at 14, how he discovered the truth about printing-press pioneer Johannes Gutenberg, and when A.I. first blew his mind.

128. Are Our Tools Becoming Part of Us?

After Haiti’s devastating earthquake, Rajiv Shah headed the largest humanitarian effort in U.S. history. As chief economist of the Gates Foundation he tried to immunize almost a billion children. He tells Steve why it’s important to take big gambles, follow the data, and own up to your mistakes.

129. How to Fix Medical Research

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