In this episode, Dr. Osterholm and Chris Dall discuss national and international COVID trends, the low uptake in the latest COVID vaccine, and share thoughts about which infectious agents have pandemic potential. Dr. Osterholm also answers an ID query about influenza vaccination and shares a moment of joy from one of our listeners.

Episode 143: Immunological Chess Match

A weekly report on the COVID-19 pandemic from infectious disease expert Michael Osterholm, PhD, MPH. Dr. Osterholm is the director of the Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota and has spent a career investigating outbreaks. Since 2005, he has emphasized supply chain and other vulnerabilities and a critical need for pandemic preparedness. In this podcast, Dr. Osterholm dissects the latest COVID-19 news, data, and guidance.
CIDRAP’s Chris Dall, MA, is the cohost of the Osterholm Update and a reporter for CIDRAP News. http://www.cidrap.umn.edu

Science

In "Brighter Days Ahead," Dr. Osterholm and Chris Dall discuss the latest national and international COVID trends, recent research on long COVID, and measles cases in the U.S. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews two members of the podcast team.
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Three studies spotlight long-term burden of COVID in US adults (Van Beusekom, CIDRAP News)
Lessons in persistence: new long COVID trials aim to clear lingering virus—and help patients in dire need (Couzin-Frankel, Science)
The pandemic’s true death toll (The Economist)
Superbugs &amp; You podcast
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Episode 155: Brighter Days Ahead

In "H5N1 Uncertainty," Dr. Osterholm and Chris Dall discuss the latest national COVID trends, a recent study on Paxlovid, and H5N1 avian flu virus infection in cattle. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews two members of the podcast team.
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Swedish study suggests link between long COVID and severity of illness&nbsp;(Stephanie Soucheray,&nbsp;CIDRAP News)
Study: long COVID affects 8% of those with COVID-19, is more common in women (Stephanie Soucheray,&nbsp;CIDRAP News)
New neurologic issues less likely after severe COVID than flu, research suggests (Mary Van Beusekom,&nbsp;CIDRAP News)
Nirmatrelvir for vaccinated or unvaccinated adult outpatients with COVID-19 (Hammond et al.,&nbsp;New England Journal of Medicine)
Treating acute COVID-19 — final chapters still unwritten (Gandhi &amp; Hirsch,&nbsp;New England Journal of Medicine)
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Episode 154: H5N1 Uncertainty

In "Good News in a COVID-Indifferent World," Dr. Osterholm and Chris Dall discuss the national and international COVID trends, the latest research on long COVID, and antibiotic-resistant Shigella. Dr. Osterholm also shares the latest "This Week in Public Health History" segment and interviews members of the podcast team.&nbsp;

	Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19 (Hanson et al.,&nbsp;Nature Immunology)

	How Americans view the coronavirus, COVID-19 vaccines amid declining levels of concern (Tyson &amp; Pasquini,&nbsp;Pew Research Center)

	Spike in extensively drug-resistant Shigella cases reported in UK, Europe (Dall,&nbsp;CIDRAP News)

	CDC warns of increase in extensively drug-resistant shigellosis (Dall,&nbsp;CIDRAP News)

	Superbugs &amp; You podcast — new episode&nbsp;coming 3/26!

	The man in the iron lung (McRobbie, The Guardian)

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Episode 153: Good News in a COVID-Indifferent World

In "A Tough Conversation," Dr. Osterholm and Chris Dall discuss the new CDC COVID isolation guidelines, a measles outbreak in Florida, and the latest news on avian influenza.&nbsp;Dr. Osterholm also provides an update on influenza and RSV cases in the U.S. and shares the latest "This Week in Public Health History" segment.

	Background for CDC’s Updated Respiratory Virus Guidance (CDC)

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Episode 152: A Tough Conversation

In this episode, Dr. Osterholm and Chris Dall discuss COVID isolation guidelines, the BA.2.87.1 variant, and the importance of measles and other rare public health threats.&nbsp;

Episode 143: Immunological Chess Match

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