Shermer and Cobb discuss: objections to genetic engineering (political, religious, cultural) • selective breeding • recombinant DNA • the ethics of genetics • patenting life • gene therapy • gene editing • CRISPR • literature and films on the dangers of genetic engineering • bioweapons • 3 Laws of Behavior Genetics and what people fear about it. Matthew Cobb is a professor in the School of Biological Sciences at the University of Manchester. He is the author of six books: The Idea of the Brain: A History; Life’s Greatest Secret: The Race to Crack the Genetic Code; Generation; The Resistance: The French Fight Against the Nazis; Eleven Days in August: The Liberation of Paris in 1944; and Smell: A Very Short Introduction. He lives in England.

313. Matthew Cobb — As Gods: A Moral History of the Genetic Age

The Michael Shermer Show is a series of long-form conversations between Dr. Michael Shermer and leading scientists, philosophers, historians, scholars, writers and thinkers about the most important issues of our time.

Natural Sciences

Science & Medicine

Science

Sean Carroll is creating a profoundly new approach to sharing physics with a broad audience, one that goes beyond analogies to show how physicists really think. He cuts to the bare mathematical essence of our most profound theories, explaining every step in a uniquely accessible way. Quantum field theory is how modern physics describes nature at its most profound level. Starting with the basics of quantum mechanics itself, Sean Carroll explains measurement and entanglement before explaining how the world is really made of fields. You will finally understand why matter is solid, why there is antimatter, where the sizes of atoms come from, and why the predictions of quantum field theory are so spectacularly successful. Fundamental ideas like spin, symmetry, Feynman diagrams, and the Higgs mechanism are explained for real, not just through amusing stories. Beyond Newton, beyond Einstein, and all the intuitive notions that have guided homo sapiens for millennia, this book is a journey to a once unimaginable truth about what our universe is. Sean Carroll is Homewood Professor of Natural Philosophy at Johns Hopkins University, and Fractal Faculty at the Santa Fe Institute. He is host of the Mindscape podcast, and author of From Eternity to Here, The Particle at the End of the Universe, The Big Picture, and Something Deeply Hidden. He has been awarded prizes and fellowships by the National Science Foundation, NASA, the American Institute of Physics, the Royal Society of London, and many others. He lives in Baltimore with his wife, writer Jennifer Ouellette. His new book series, The Biggest Ideas in the Universe, includes one volume on Space, Time, and Motion, and this new volume on Quanta and Fields. Shermer and Carroll discuss: the measurement problem in physics • wave functions • entanglement • fields • interactions • scale • symmetry • gauge theory • phases • matter • atoms • time • double-slit experiment • superposition • directionality in nature • the multiverse • known unknowables • Is there a place for God in scientific epistemology?

Quanta and Fields

As a Hillary voter, a New York Times reporter, and frequent attendee at her local gay bars, Nellie Bowles fit right in with her San Francisco neighbors and friends—until she started questioning whether the progressive movement she knew and loved was actually helping people. When her colleagues suggested that asking such questions meant she was “on the wrong side of history,” Bowles did what any reporter worth her salt would do: she started investigating for herself. The answers she found were stranger—and funnier—than she expected. In Morning After the Revolution, Bowles gives readers a front-row seat to the absurd drama of a political movement gone mad. With irreverent accounts of attending a multiday course on “The Toxic Trends of Whiteness,” following the social justice activists who run “Abolitionist Entertainment LLC,” and trying to please the New York Times’s “disinformation czar,” she deftly exposes the more comic excesses of a movement that went from a sideshow to the very center of American life. Deliciously funny and painfully insightful, Morning After the Revolution is a moment of collective psychosis preserved in amber. This is an unmissable debut by one of America’s sharpest journalists. Nellie Bowles is a writer living in Los Angeles. Previously, she was a correspondent at The New York Times where, as part of a team, she won the Gerald Loeb Award in Investigations and the Robert F. Kennedy Human Rights Journalism Award. Now she is working with her wife, Bari Weiss, to build The Free Press, a new media company, where she also writes the weekly TGIF column which is released every Friday, thank God…or whoever. Shermer and Bowles discuss: what it’s like to work at The New York Times • what it’s like to found a new media company • same-sex marriage • Liberalism vs. Progressivism • the Black Lives Matter, #metoo, and transgender movements • Patrisse Khan-Cullors • White privilege • somatic abolitionism • LGBTQ • IDAHOBIT • BBIPOC • CHAZ • homelessness • anti-racism • cancel culture • defund the police • protests.

Reporting From the Frontlines of the Culture Wars

In Then I Am Myself the World, Christof Koch explores the only thing we directly experience: consciousness. At the book’s heart is integrated-information theory, the idea that the essence of consciousness is the ability to exert causal power over itself, to be an agent of change. Koch investigates the physical origins of consciousness in the brain and how this knowledge can be used to measure consciousness in natural and artificial systems. Enabled by such tools, Koch reveals when and where consciousness exists, and uses that knowledge to confront major social and scientific questions: When does a fetus first become self-aware? Can psychedelic and mystical experiences transform lives? What happens to consciousness in near-death experiences? Why will generative AI ultimately be able to do the very thing we can do, yet never feel any of it? And do our experiences reveal a single, objective reality?    Christof Koch is a neuroscientist at the Allen Institute and at the Tiny Blue Dot Foundation, the former president of the Allen Institute for Brain Science, and a former professor at the California Institute of Technology. Author of four previous titles — The Feeling of Life Itself: Why Consciousness Is Widespread but Can’t Be Computed, Consciousness: Confessions of a Romantic Reductionist, and The Quest for Consciousness: A Neurobiological Approach — Koch writes regularly for a range of media, including Scientific American. He lives in the Pacific Northwest. Shermer and Koch discuss: “subjective experience” • the author’s near-death experience changed him • the difficulties of materialism/physicalism • a fundamental theory of consciousness that explains subjective experiences in objective measures • designing a “consciousness detector” for unresponsive patients • why magic mushrooms and Ayahuasca are of so fascinating to neuroscientists • how our minds are shaped by our beliefs, prior experiences, and intentions • insights crucial to those suffering from anxiety, low self-esteem, post-traumatic stress, and depression. • the future of advanced brain-machine interfaces • why digital computers will never be conscious.

How to Expand Consciousness

At its simplest, Bayes’s theorem describes the probability of an event, based on prior knowledge of conditions that might be related to the event. But in Everything Is Predictable, Tom Chivers lays out how it affects every aspect of our lives. He explains why highly accurate screening tests can lead to false positives and how a failure to account for it in court has put innocent people in jail. A cornerstone of rational thought, many argue that Bayes’s theorem is a description of almost everything. But who was the man who lent his name to this theorem? How did an 18th-century Presbyterian minister and amateur mathematician uncover a theorem that would affect fields as diverse as medicine, law, and artificial intelligence? Fusing biography and intellectual history, Everything Is Predictable is an entertaining tour of Bayes’s theorem and its impact on modern life, showing how a single compelling idea can have far reaching consequences. Tom Chivers is an author and the award-winning science writer for Semafor. Previously he was the science editor at UnHerd.com and BuzzFeed UK. His writing has appeared in The Times (London), The Guardian, New Scientist, Wired, CNN, and more. He was awarded the Royal Statistical Society’s “Statistical Excellence in Journalism” awards in 2018 and 2020, and was declared the science writer of the year by the Association of British Science Writers in 2021. His books include The Rationalist’s Guide to the Galaxy: Superintelligent AI and the Geeks Who Are Trying to Save Humanity’s Future, and How to Read Numbers: A Guide to Stats in the News (and Knowing When to Trust Them). His new book is Everything Is Predictable: How Bayesian Statistics Explain Our World. Shermer and Chivers discuss: Thomas Bayes, his equation, and the problem it solves • Bayesian decision theory vs. statistical decision theory • Popperian falsification vs. Bayesian estimation • Sagan’s ECREE principle • Bayesian epistemology and family resemblance • paradox of the heap • Reality as controlled hallucination • human irrationality • superforecasting • mystical experiences and religious truths • Replication Crisis in science • Statistical Detection Theory and Signal Detection Theory • Medical diagnosis problem and why most people get it wrong.

Everything is Predictable: How Bayesian Statistics Explain Our World

For thousands of years, humans have wondered whether we’re alone in the cosmos. Now, for the first time, we have the technology to investigate. But once you look for life elsewhere, you realize it is not so simple. How do you find it over cosmic distances? What actually is life? As founding director of Cornell University’s Carl Sagan Institute, astrophysicist Lisa Kaltenegger has built a team of tenacious scientists from many disciplines to create a specialized toolkit to find life on faraway worlds. In Alien Earths, she demonstrates how we can use our homeworld as a Rosetta Stone, creatively analyzing Earth’s history and its astonishing biosphere to inform this search. With infectious enthusiasm, she takes us on an eye-opening journey to the most unusual exoplanets that have shaken our worldview - planets covered in oceans of lava, lonely wanderers lost in space, and others with more than one sun in their sky! And the best contenders for Alien Earths. We also see the imagined worlds of science fiction and how close they come to reality. With the James Webb Space Telescope and Dr. Kaltenegger’s pioneering work, she shows that we live in an incredible new epoch of exploration. As our witty and knowledgeable tour guide, Dr. Kaltenegger shows how we discover not merely new continents, like the explorers of old, but whole new worlds circling other stars and how we could spot life there. Worlds from where aliens may even be gazing back at us. What if we’re not alone? Lisa Kaltenegger is the Director of the Carl Sagan Institute to Search for Life in the Cosmos at Cornell and Associate Professor in Astronomy. She is a pioneer and world-leading expert in modeling potential habitable worlds and their detectable spectral fingerprint. Kaltenegger serves on the National Science Foundation’s Astronomy and Astrophysics Advisory Committee (AAAC), and on NASA senior review of operating missions. She is a Science Team Member of NASA’s TESS Mission as well as the NIRISS instrument on James Webb Space Telescope. Kaltenegger was named one of America’s Young Innovators by Smithsonian magazine, an Innovator to Watch by Time magazine. She appears in the IMAX 3D movie “The Search for Life in Space” and speaks frequently, including at Aspen Ideas Festival, TED Youth, World Science Festival and the Kavli Foundation lecture at the Adler Planetarium. Shermer and Kaltenegger discuss: Carl Sagan and his influence • Sagan’s Dragon • ECREE Principle • how stars, planets and solar systems form • how exoplanets are discovered • Hubble Space Telescope, Kepler Space Telescope, James Webb Space Telescope • The Origin of Life • Fermi’s Paradox: where is everybody (the Great Silence, the Great Filter) • biosignatures • technosignatures • Dyson spheres • Will aliens be biological or AI? • interstellar travel • Kardashev scale of civilizations • how to talk to aliens when we can’t even talk to dolphins • Deities for Atheists, Skygods for Skeptics: aliens as gods and the search as religion • why alien worlds matter.

313. Matthew Cobb — As Gods: A Moral History of the Genetic Age

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