Social affairs correspondent Robert Booth tells Madeleine Finlay why a class of synthetic opioids called nitazenes, first developed in the 1950s, is leading to a worrying number of fatal overdoses in the UK. And she hears from toxicology and addiction specialist Dr Joseph D’Orazio about a tranquilliser called xylazine that has been showing up in alarming volumes in the US illegal drug supply and is now starting to appear in toxicology reports in the UK. Help support our independent journalism at theguardian.com/sciencepod

Nitazenes and xylazine: what’s behind the rise of dangerous synthetic drugs?

Twice a week, the Guardian brings you the latest science and environment news

Science

Glioblastomas are an extremely aggressive type of brain tumour, which is why the news this week of a vaccine that has shown promise in fighting them is so exciting. And this comes right off the back of the announcement of another trial of the world’s first personalised mRNA vaccine for melanoma, a kind of skin cancer. Ian Sample talks to Prof Alan Melcher of the Institute of Cancer Research about how these vaccines work and whether they could one day be used to target cancer before it is even detectable on scans. Help support our independent journalism at theguardian.com/sciencepod

The extraordinary promise of personalised cancer vaccines

Guardian Seascapes reporter Karen McVeigh tells Madeleine Finlay about a recent trip to the Galápagos Islands, where mounds of plastic waste are washing up and causing problems for endemic species. Tackling this kind of waste and the overproduction of plastic were the topics on the table in Ottawa this week, as countries met to negotiate a global plastics treaty. But is progress too slow to address this pervasive problem?. Help support our independent journalism at theguardian.com/sciencepod

The stream of plastic pollution: could a global treaty help us turn off the tap?

As bird flu is confirmed in 33 cattle herds across eight US states, Ian Sample talks to virologist Dr Ed Hutchinson of Glasgow University about why this development has taken scientists by surprise, and how prepared we are for the possibility it might start spreading among humans. Help support our independent journalism at theguardian.com/sciencepod

From birds, to cattle, to … us? Could bird flu be the next pandemic?

Labradors are known for being greedy dogs, and now scientists have come up with a theory about the genetic factors that might be behind their behaviour. Science correspondent and flat-coated retriever owner Nicola Davis visits Cambridge University to meet Dr Eleanor Raffan and Prof Giles Yeo to find out how understanding this pathway could help us treat the obesity crisis in humans. Help support our independent journalism at theguardian.com/sciencepod

Hardwired to eat: what can our dogs teach us about obesity?

Billed as a rival to the Olympic Games, the Enhanced Games, set to take place in 2025, is a sporting event with a difference; athletes will be allowed to dope. Ian Sample talks to chief sports writer Barney Ronay about where the idea came from and how it’s being sold as an anti-establishment underdog, and to Dr Peter Angell about what these usually banned substances are, and what they could do to athletes’ bodies. Help support our independent journalism at theguardian.com/sciencepod

Nitazenes and xylazine: what’s behind the rise of dangerous synthetic drugs?

Download our free app to listen on your phone