Out of the Blue: An AJRCCM Podcast

By American Thoracic Society

What's Out of the Blue: An AJRCCM Podcast about?

The Out of the Blue podcast takes you out of the pages of the American Journal of Respiratory and Critical Care Medicine and into the minds of the most brilliant researchers in the fields of respiratory, critical care, and sleep medicine.

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Out of the Blue: An AJRCCM Podcast episodes:

06.05.2024
Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea
Dr. John Fleetham chats with Dr. Gozal on his article, "Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea."
03.28.2024
Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Dr. John Fleetham chats with Dr. Bijan Teja and Dr. Nicholas Bosch about their article, "Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials."
02.21.2024
Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation and Inhaled Microplastics and Airway Development: Concerning Evidence from Organoids
Dr. John Fleetham chats with Dr. Barbro N Melgert and Dr. Chris Carlsten about their articles, "Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation" and "Inhaled Microplastics and Airway Development: Concerning Evidence from Organoids."
01.17.2024
A New Global Definition of Acute Respiratory Distress Syndrome
Dr. Michael Lanspa chats with Dr. Michael Matthay about his article, "A New Global Definition of Acute Respiratory Distress Syndrome."
01.16.2024
External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources and The Added Power of Synthetic Control Groups: Challenging Conventional Wisdom and Trial Desig
Dr. Mohleen Kang chats with Dr. Aparna Swaminathan and Dr. Timothy Dempsey about their articles, "External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources” and “The Added Power of Synthetic Control Groups: Challenging Conventional Wisdom...
12.08.2023
The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial and Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seei
Dr. John Fleetham chats with Dr. Paula K. Schweitzer and Dr. Najib Ayas about their articles, "The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial" and "Pharmacologic Therapy for Obstructive Sleep...
10.05.2023
FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease
Dr. John Fleetham chats with Dr. Surya Bhatt about his article, “FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease.”
09.28.2023
Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial
Dr Michael Lanspa chats with Dr. Imeen van der Wal and Dr. Chloe Grim on their article, "Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial."
07.20.2023
Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea
Dr. John Fleetham chats with Dr. Raphael Heinzer about his article, "Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea."
06.22.2023
Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness
Dr. Michael Lanspa chats with Dr. Kevin Seitz and Dr. Matthew Churpek about their article, "Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness."
05.11.2023
Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis
Dr. John Fleetham chats with Dr. Molly Franke and Dr. James Brust about their articles, "Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis" and “Weighting” the evidence: How much bedaquiline is enough?"
03.23.2023
Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)
Dr. Michael Lanspa chats with Dr. Yahya Shehabi about his article, "Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)."
03.02.2023
Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California
Dr. John Fleetham chats with Dr. Joseph Lewnard and Dr. Will Checkley about their articles, "Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California" and "Tuberculosis, Wildfires, and Case-crossover Studies: An Epidemiological Trifecta."
12.15.2022
Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results
Paper discussed in today's episode: Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results
12.01.2022
Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness
Papers discussed in today's episode: Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness Continuous Positive Airway Pressure and Cardiovascular Risk Reduction in Patients without Excessive Sleepiness: Importance of the Pulse...
11.24.2022
High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial
Paper discussed in today's episode: High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial
09.01.2022
Autoimmune Pulmonary Alveolar Proteinosis
Article discussed in this episode: Autoimmune Pulmonary Alveolar Proteinosis
08.18.2022
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis
Article discussed in this episode: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis
08.11.2022
Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities
Article discussed in this episode: Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities
06.09.2022
A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea
Articles discussed in this episode: “A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea" “Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?”
04.21.2022
Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
Article discussed in this episode: Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
03.17.2022
Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype
Article discussed in this episode: Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype: A Randomized Clinical Trial
02.22.2022
Using Isoniazid More Safely and More Effectively in Tuberculosis Treatment
Articles discussed in today's episode: A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment A Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-Resistant Tuberculosis: Results from a Randomized Clinical Trial Using Isoniazid More Safely...
01.20.2022
Multi-night Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea
Article discussed in today's episode: Multi-night Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea
12.23.2021
Alpha-1 Antitrypsin MZ Heterozygosity is an Endotype of COPD
Article discussed in today's episode: Alpha-1 Antitrypsin MZ Heterozygosity is an Endotype of Chronic Obstructive Pulmonary Disease
12.09.2021
Latent Class Analysis in COVID-19
Article discussed in today's episode: Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids
10.28.2021
Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from ARDS
Article discussed in today's episode: Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-Based and Mechanistic Reanalysis of the EPVent-2 Trial
10.14.2021
Association Between PAP Device Manufacturer and Incident Cancer?: A Secondary Data Analysis
Paper discussed in today's episode: An Association Between Positive Airway Pressure (PAP) Device Manufacturer and Incident Cancer?: A Secondary Data Analysis
09.30.2021
Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications
Article discussed in today's episode: Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications
09.16.2021
Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury
Article discussed in today's episode: Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury
08.26.2021
Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea
Article discussed in today's episode: Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea: A Randomized Controlled Trial
08.05.2021
Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain
Article discussed in today's episode: Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain
06.25.2021
Effectiveness of Protective Ventilation Strategies for Moderate and Severe ARDS
Article discussed in today's episode: Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe Acute Respiratory Distress Syndrome. A Network Meta-Analysis
06.10.2021
Antigen-Specific T Cell Activation Distinguishes Between Recent and Remote TB Infection
Article discussed in today's episode: Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection Dr. Escalante's editorial on the paper: New Diagnostics to Infer Risk in Tuberculosis: Is the Term Latent Tuberculosis Infection Obsolete?
05.27.2021
Lung Ultrasound to Monitor Extremely Preterm Infants and Predict BPD
Article discussed in today's episode: Lung Ultrasound to Monitor Extremely Preterm Infants and Predict BPD: Multicenter Longitudinal Cohort Study
05.13.2021
Tidal Volume and Respiratory Compliance in ARDS
Article discussed in today's episode: Effect of Lowering Tidal Volume on Mortality in ARDS Varies with Respiratory System Elastance
04.29.2021
Viral Dispersion Associated with Respiratory Support Devices in a Simulated Critical Care Environment
Article discussed in today's episode: Quantitative Assessment of Viral Dispersion Associated with Respiratory Support Devices in a Simulated Critical Care Environment
04.15.2021
CPAP Restores Declarative Memory Deficit in Obstructive Sleep Apnea
Article discussed in today's episode: CPAP Restores Declarative Memory Deficit in Obstructive Sleep Apnea
03.17.2021
COVID-19 and the AJRCCM: A Year in Review
Dr. Michael Lanspa sits down with AJRCCM editor Dr. Sanjay H. Chotirmall to discuss some of the most impactful COVID papers published in the AJRCCM over the past year and what we can expect moving forward.
12.31.2020
Best of the Blue in 2020
Podcasts discussed in today's episode: Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock Treatment of Drug-Resistant Tuberculosis ATS Guideline on Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic COPD ATS Guideline on Home Oxygen...
12.10.2020
ATS Guideline on Home Oxygen Therapy for Adults with Chronic Lung Disease
Article discussed in today's episode: Home Oxygen Therapy for Adults with Chronic Lung Disease. An Official American Thoracic Society Clinical Practice Guideline
11.25.2020
Cardiopulmonary Resuscitation-Associated Lung Edema (CRALE)
Article discussed in today's episode: Cardiopulmonary Resuscitation-Associated Lung Edema (CRALE) - A Translational Study
11.12.2020
ATS Guideline on Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic COPD
Article discussed in today's episode: Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline
10.29.2020
Tissue Doppler Imaging of the Diaphragm in Healthy Subjects and Critically Ill Patients
Article discussed in today's episode: Tissue Doppler Imaging of the Diaphragm in Healthy Subjects and Critically Ill Patients
09.10.2020
Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock
Link to the article discussed: Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock
08.06.2020
Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia
Article discussed in today's episode: Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia
07.23.2020
Relative Hypotension and Adverse Kidney-Related Outcomes Among Critically Ill Patients with Shock
Paper discussed in today's episode: Relative Hypotension and Adverse Kidney-related Outcomes Among Critically Ill Patients with Shock- A Multicenter Prospective Cohort Study
07.09.2020
The COVID-19 Pandemic Presents an Opportunity to Reassess the Value of Polysomnography
Articles discussed in today's episode: The COVID-19 Pandemic Presents an Opportunity to Reassess the Value of Polysomnography The Baby, the Bathwater, and the Polysomnogram
06.04.2020
Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A
Article discussed in today's episode: Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A
05.21.2020
Association of Pre-Morbid Blood Pressure with Vasopressor Infusion Duration in Patients with Shock
Article discussed in today's episode: Association of Pre-Morbid Blood Pressure with Vasopressor Infusion Duration in Patients with Shock

What's Out of the Blue: An AJRCCM Podcast about?

Download our free app to listen on your phone

Out of the Blue: An AJRCCM Podcast episodes:

Senolytic-facilitated Reversal of End-Organ Dysfunction in a Murine Model of Obstructive Sleep Apnea

Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation and Inhaled Microplastics and Airway Development: Concerning Evidence from Organoids

A New Global Definition of Acute Respiratory Distress Syndrome

External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources and The Added Power of Synthetic Control Groups: Challenging Conventional Wisdom and Trial Desig

The Combination of Aroxybutynin and Atomoxetine in the Treatment of Obstructive Sleep Apnea (MARIPOSA): A Randomized Controlled Trial and Pharmacologic Therapy for Obstructive Sleep Apnea: Are We Seei

FEV1/FVC Severity Stages for Chronic Obstructive Pulmonary Disease

Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial

Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea

Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness

Effectiveness of Bedaquiline Use Beyond Six Months in Patients with Multidrug-Resistant Tuberculosis

Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose Associated 90-day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE-III)

Tuberculosis Diagnoses Following Wildfire Smoke Exposure in California

Assessing Pretomanid for Tuberculosis (APT), a Randomized Phase 2 Trial of Pretomanid-containing Regimens for Drug-sensitive TB: 12-Week Results

Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness

High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial

Autoimmune Pulmonary Alveolar Proteinosis

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis

Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities

A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea

Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions

Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype

Using Isoniazid More Safely and More Effectively in Tuberculosis Treatment

Multi-night Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea

Alpha-1 Antitrypsin MZ Heterozygosity is an Endotype of COPD

Latent Class Analysis in COVID-19

Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from ARDS

Association Between PAP Device Manufacturer and Incident Cancer?: A Secondary Data Analysis

Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications

Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury

Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea

Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain

Effectiveness of Protective Ventilation Strategies for Moderate and Severe ARDS

Antigen-Specific T Cell Activation Distinguishes Between Recent and Remote TB Infection

Lung Ultrasound to Monitor Extremely Preterm Infants and Predict BPD

Tidal Volume and Respiratory Compliance in ARDS

Viral Dispersion Associated with Respiratory Support Devices in a Simulated Critical Care Environment

CPAP Restores Declarative Memory Deficit in Obstructive Sleep Apnea

COVID-19 and the AJRCCM: A Year in Review

Best of the Blue in 2020

ATS Guideline on Home Oxygen Therapy for Adults with Chronic Lung Disease

Cardiopulmonary Resuscitation-Associated Lung Edema (CRALE)

ATS Guideline on Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic COPD

Tissue Doppler Imaging of the Diaphragm in Healthy Subjects and Critically Ill Patients

Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock

Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia

Relative Hypotension and Adverse Kidney-Related Outcomes Among Critically Ill Patients with Shock

The COVID-19 Pandemic Presents an Opportunity to Reassess the Value of Polysomnography

Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A

Association of Pre-Morbid Blood Pressure with Vasopressor Infusion Duration in Patients with Shock

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