A 38-year-old woman with type 2 diabetes has a telemedicine visit after learning that a person with whom she had close contact at an indoor wedding 3 days earlier has tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The woman reports that she is asymptomatic and received a second vaccination against SARS-CoV-2 approximately 9 months ago but has not received a booster vaccination. She attended the wedding with her husband, who has also received two vaccinations, and her two unvaccinated children, who are 5 and 8 years of age. Her husband had mild nasal congestion and a cough the evening before her appointment. She had previously purchased rapid diagnostic tests that received emergency use authorization from the Food and Drug Administration for home-based SARS-CoV-2 testing and wonders whether using these tests would be appropriate. What would you advise? Full-text recordings of Clinical Practice articles may be found at NEJM.org.

Rapid Diagnostic Testing for SARS-CoV-2 by P.K. Drain

Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.

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Featuring articles on T-cell cancer after CAR T-cell therapy, the early diagnosis and treatment of COPD and asthma, and the implications of race adjustment in lung-function equations; a review article on diets; a case report of a woman with the worst headache of her life; and Perspectives on efforts toward equity and on feeling guilty.

NEJM This Week — June 13, 2024

Featuring articles on neoadjuvant immunotherapy for dMMR colon cancer, TAVR in patients with a small aortic annulus, gene editing and retinal degeneration, and the genetic diagnosis of rare diseases; a review article on disorders of magnesium; a case report of a woman with metastatic breast cancer; and a Perspective on malicious midwives, fruitful vines, and bearded women.

NEJM This Week — June 6, 2024

Featuring articles on aficamten for obstructive hypertrophic cardiomyopathy; early blood-pressure reduction in acute stroke; interferon-γ in autoimmune polyendocrine syndrome type 1; video laryngoscopy for intubation in neonates; hunger, thirst, and Buridan’s ass; and global health law for a safer and fairer world; a review article on medical AI and human values; a case report of a man with a pustular rash; and Perspectives on an approach toward a tobacco-free generation, on fair allocation of GLP-1 and dual GLP-1–GIP receptor agonists, on corporate medicine 2.0, and on snapshots.

NEJM This Week — May 30, 2024

Featuring articles on andexanet and factor Xa inhibitor–associated hemorrhage, perioperative nivolumab in resectable lung cancer, olezarsen for familial chylomicronemia syndrome, and olezarsen for hypertriglyceridemia; a review article on climate change, extreme heat, and health; a case report of a woman with worsening rash; and Perspective articles on focusing on health care equity, on underestimated challenges for social care initiatives, on integrating public health and health care, and on learning to say goodbye.

NEJM This Week — May 16, 2024

Featuring articles on gene editing in severe sickle cell disease and in transfusion-dependent β-thalassemia, thrombectomy for stroke with a large infarct, and recombinant ADAMTS13 in life-threatening immune thrombotic thrombocytopenic purpura; a review article on taste physiology; a case report of a woman with back pain, leg stiffness, and falls; and Perspective articles on the public good on the docket, on reengineering addiction, on welcoming the era of gene editing in medicine, and on all’s fair in love and work.

Rapid Diagnostic Testing for SARS-CoV-2 by P.K. Drain

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