The criminalization of psychedelic drugs did little to stop casual use, but did make it nearly impossible to do legitimate research on their effects and medicinal potential. Rick Doblin has spent most of his life trying to change that. Now, he and the organization he founded, the Multidisciplinary Association for Psychedelic Studies (MAPS), may be on the verge of a breakthrough: the first FDA approval for therapeutic use of psychedelics. On today's show, I spoke to Rick about the long road from proscription to prescription; where the previous generation of psychedelic advocates went wrong and what's going right this time; how psychedelics might work to assist psychotherapy for conditions such as PTSD, severe anxiety and drug and alcohol addiction; and how that model differs from conventional psychopharmaceutical approaches. Also Rick talks about his own psychedelic experiences and why mind-altering drugs can be so life-altering.

Rick Doblin: Psychedelics and Psychotherapy

A podcast exploring questions in science, culture, music, philosophy and more. Life as we know it, or would like to. The content varies from episode to episode and includes interviews, music and the occasional sound-rich story in the tradition of This American Life or Radio Lab. Produced and hosted by Robert Pollie in California.

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There are a lot of comedians whose work I'm partial to, but I have a special place in my pantheon for Garry Shandling. He was funny, unsparing, compassionate, psychologically acute and epistemologically astute all at once, an uneasy combination of entertainer and truth-seeker. When I learned of his untimely death on March 24, like many fans I felt bereaved, and I sought out someone to talk to who loved his work as much as I do: Paul Provenza. Paul is a comedian and a sort of comedy curator, chronicler and catalyst, and he was responsible for one of Garry's more memorable public appearances, which I was fortunate enough to attend thanks to Paul. We talked about Garry the person and the performer – and the complicated relationship thereof.

Remembering Comedian Garry Shandling with Paul Provenza

If the news coverage of recently discovered gravitational waves left you with lingering questions, you've come to the right place. Theoretical physicist Anthony Aguirre, our go-to guy on all things general relativistic, provides some great insight into the details and subtleties that popular accounts ignored or glossed over.

Gravity Waves Explained by Physicist Anthony Aguirre

Gwendolyn Mok may have flunked her first Juilliard audition at the age of 5, but that was just a speed bump en route to a distinguished recording and concert career. Gwen sees herself as a kind of medium, doing her best to channel the spirit and intentions of composers such as Brahms, Mendelssohn, Saint-Saëns, and particularly Ravel. Her brand of originalism extends to playing historic pianos like those the composers themselves knew and wrote for, and Gwen demonstrated with some exquisite renditions on an 1868 Erard and 1871 Streicher as we talked about her life as a student, performer and teacher. Also discussed: her school days with Yo Yo Ma, apprenticing with Ravel's last living student, performing with Astor Piazzolla, driving the Silk Road in a 1940 Chevy, making mistakes in concert, and the best place to listen to a piano.

Gwendolyn Mok: Pianist and Musical Medium

“As a black male in the United States,” says George Yancy, “to do philosophy in the abstract would be to deny the reality of my own existence.” Yancy grew up in a tough North Philadelphia housing project, where young men were far more likely to end up in early graves or jail than in academia. He beat the odds and now enjoys the status of a tenured professor at a major university, but he hasn't forgotten where he came from, or the racial realities that made his story so unlikely. George and I talked about his beginnings, becoming a philosopher and using his brand of "down to earth" philosophizing to explore the structure of blackness, whiteness and lived experience in a racialized society.

George Yancy: Philosophizing While Black

It's one thing to genetically modify an organism in the lab. It's another thing entirely to spread those modifications in the wild, altering whole populations or even species. A new technology, the “CRISPR gene drive,” promises to do just that, giving human beings an unprecedented ability to fine-tune the natural world and nudge evolution in new directions. Malaria-resistant mosquitoes? Lyme-blocking ticks? Those are just a few of the applications floated so far, but the possibilities are endless. I talked to molecular biologist and “evolutionary sculptor” Kevin Esvelt, who first proposed the CRISPR gene drive, about its potential, perils and steps to ensure that we use our new powers wisely.

Rick Doblin: Psychedelics and Psychotherapy

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