We are on the cusp of a major transformation in healthcare. Using information gleaned from our blood and genes and tapping into the data revolution made possible by AI, doctors can catch the onset of disease years before symptoms arise, revolutionizing prevention. At top hospitals and a few innovative health-tech startups, scientists are working closely with patients to dramatically extend their “healthspan”―the number of healthy years before disease sets in. In The Age of Scientific Wellness, two visionary leaders of this revolution in health take us on a thrilling journey to this new frontier of medicine. Hood, Price, and Shermer discuss: why we age and die • sickcare vs. healthcare • the 10 most popular drugs in the U.S. work for only about 10% of treated people • chronological age ≠ biological age • life expectancy, life span, longevity, and healthspan • why eliminating all cancers would only increase average life span by 3 years • genome vs. phenome • gut biome • optimizing brain function • brain plasticity • sleep, nutrition, exercise • Alzheimer’s • AI and quantum computing for better health.

The Future of Medicine: What You Need to Know

The Michael Shermer Show is a series of long-form conversations between Dr. Michael Shermer and leading scientists, philosophers, historians, scholars, writers and thinkers about the most important issues of our time.

Natural Sciences

Science & Medicine

Science

At its simplest, Bayes’s theorem describes the probability of an event, based on prior knowledge of conditions that might be related to the event. But in Everything Is Predictable, Tom Chivers lays out how it affects every aspect of our lives. He explains why highly accurate screening tests can lead to false positives and how a failure to account for it in court has put innocent people in jail. A cornerstone of rational thought, many argue that Bayes’s theorem is a description of almost everything. But who was the man who lent his name to this theorem? How did an 18th-century Presbyterian minister and amateur mathematician uncover a theorem that would affect fields as diverse as medicine, law, and artificial intelligence? Fusing biography and intellectual history, Everything Is Predictable is an entertaining tour of Bayes’s theorem and its impact on modern life, showing how a single compelling idea can have far reaching consequences. Tom Chivers is an author and the award-winning science writer for Semafor. Previously he was the science editor at UnHerd.com and BuzzFeed UK. His writing has appeared in The Times (London), The Guardian, New Scientist, Wired, CNN, and more. He was awarded the Royal Statistical Society’s “Statistical Excellence in Journalism” awards in 2018 and 2020, and was declared the science writer of the year by the Association of British Science Writers in 2021. His books include The Rationalist’s Guide to the Galaxy: Superintelligent AI and the Geeks Who Are Trying to Save Humanity’s Future, and How to Read Numbers: A Guide to Stats in the News (and Knowing When to Trust Them). His new book is Everything Is Predictable: How Bayesian Statistics Explain Our World. Shermer and Chivers discuss: Thomas Bayes, his equation, and the problem it solves • Bayesian decision theory vs. statistical decision theory • Popperian falsification vs. Bayesian estimation • Sagan’s ECREE principle • Bayesian epistemology and family resemblance • paradox of the heap • Reality as controlled hallucination • human irrationality • superforecasting • mystical experiences and religious truths • Replication Crisis in science • Statistical Detection Theory and Signal Detection Theory • Medical diagnosis problem and why most people get it wrong.

Everything is Predictable: How Bayesian Statistics Explain Our World

For thousands of years, humans have wondered whether we’re alone in the cosmos. Now, for the first time, we have the technology to investigate. But once you look for life elsewhere, you realize it is not so simple. How do you find it over cosmic distances? What actually is life? As founding director of Cornell University’s Carl Sagan Institute, astrophysicist Lisa Kaltenegger has built a team of tenacious scientists from many disciplines to create a specialized toolkit to find life on faraway worlds. In Alien Earths, she demonstrates how we can use our homeworld as a Rosetta Stone, creatively analyzing Earth’s history and its astonishing biosphere to inform this search. With infectious enthusiasm, she takes us on an eye-opening journey to the most unusual exoplanets that have shaken our worldview - planets covered in oceans of lava, lonely wanderers lost in space, and others with more than one sun in their sky! And the best contenders for Alien Earths. We also see the imagined worlds of science fiction and how close they come to reality. With the James Webb Space Telescope and Dr. Kaltenegger’s pioneering work, she shows that we live in an incredible new epoch of exploration. As our witty and knowledgeable tour guide, Dr. Kaltenegger shows how we discover not merely new continents, like the explorers of old, but whole new worlds circling other stars and how we could spot life there. Worlds from where aliens may even be gazing back at us. What if we’re not alone? Lisa Kaltenegger is the Director of the Carl Sagan Institute to Search for Life in the Cosmos at Cornell and Associate Professor in Astronomy. She is a pioneer and world-leading expert in modeling potential habitable worlds and their detectable spectral fingerprint. Kaltenegger serves on the National Science Foundation’s Astronomy and Astrophysics Advisory Committee (AAAC), and on NASA senior review of operating missions. She is a Science Team Member of NASA’s TESS Mission as well as the NIRISS instrument on James Webb Space Telescope. Kaltenegger was named one of America’s Young Innovators by Smithsonian magazine, an Innovator to Watch by Time magazine. She appears in the IMAX 3D movie “The Search for Life in Space” and speaks frequently, including at Aspen Ideas Festival, TED Youth, World Science Festival and the Kavli Foundation lecture at the Adler Planetarium. Shermer and Kaltenegger discuss: Carl Sagan and his influence • Sagan’s Dragon • ECREE Principle • how stars, planets and solar systems form • how exoplanets are discovered • Hubble Space Telescope, Kepler Space Telescope, James Webb Space Telescope • The Origin of Life • Fermi’s Paradox: where is everybody (the Great Silence, the Great Filter) • biosignatures • technosignatures • Dyson spheres • Will aliens be biological or AI? • interstellar travel • Kardashev scale of civilizations • how to talk to aliens when we can’t even talk to dolphins • Deities for Atheists, Skygods for Skeptics: aliens as gods and the search as religion • why alien worlds matter.

The New Science of Planet Hunting in the Cosmos

We all want to be happier, but our brains often get in the way. When we’re too stuck in our heads we obsess over our inadequacies, compare ourselves with others and fail to see the good in our lives. In The Science of Happiness, world-leading psychologist and happiness expert Bruce Hood demonstrates that the key to happiness is not self-care but connection. He presents seven simple but life-changing lessons to break negative thought patterns and re-connect with the things that really matter.  Alter Your Ego Avoid Isolation Reject Negative Comparisons Become More Optimistic Control Your Attention Connect With Others Get Out of Your Own Head  Grounded in decades of studies in neuroscience and developmental psychology, this book tells a radical new story about the roots of wellbeing and the obstacles that lie in our path. With clear, practical takeaways throughout, Professor Hood demonstrates how we can all harness the findings of this science to re-wire our thinking and transform our lives. Dr. Bruce Hood is an award-winning Professor of Developmental Psychology at Bristol University and the author of several books including SuperSense, The Self Illusion, The Domesticated Brain, and Possessed. His course, The Science of Happiness, is the most popular course at Bristol University. He has appeared extensively on TV and radio, including co-hosting the BBC podcast The Happiness Half Hour in 2021. He is a Fellow of the American Psychological Society, the Royal Institution of Great Britain and the British Psychological Society. Shermer and Hood discuss: psychedelic drugs • defining the “good life” or “happiness” • measuring emotions • happiness as social contagion • eudaimonia (the pursuit of meaning) versus hedonism (the pursuit of pleasure) • genetics and heritability • cultural components • WEIRD people • The Big Five (OCEAN) • marriage and health • exercise and stress reduction • what the ancient Greeks got right about living the good life • how failure may actually be a key to more happiness • how to live the life you want—not necessarily the life expected of you.

The Science of Happines

Robin Reames breaks down the major techniques of rhetoric, pulling back the curtain on how politicians, journalists, and “journalists” convince us to believe what we believe—and to talk, vote, and act accordingly. Understanding these techniques helps us avoid being manipulated by authority figures who don’t have our best interests at heart. It also grants us rare insight into the values that shape our own beliefs. Reames and Shermer discuss: rhetoric vs. facts (rhetorical truths vs. empirical truths) • the point of reason (to understand reality or to persuade?) • Canons of rhetoric: invention, arrangement, style, memory, delivery • bullshitters vs. liars • induction and deduction • rhetorical, ideological, and metaphorical thinking • how to debate contentious issues Robin Reames is associate professor of English at the University of Illinois at Chicago, specializing in rhetorical theory and the history of ideas. Her new book is The Ancient Art of Thinking for Yourself: The Power of Rhetoric in Polarized Times. SPONSOR: everything-everywhere.com

How Rhetoric Shapes Your Opinions

We push ourselves toward the highest-paying, most prestigious jobs, seeking promotions and public recognition. As Adam Gopnik points out, the result is not so much a rat race as a rat maze, with no way out. Except one: to choose accomplishment over achievement. Achievement is the completion of the task imposed from outside. Accomplishment, by contrast, is the end point of an engulfing activity one engages in for its own sake. Shermer and Gopnik discuss:  mastering the secrets of stage magic (Gopnik's son worked with David Blaine and Jamy Ian Swiss) accomplishment in music family and mentors the concept of the 10,000-hour rule vs. natural talent Adam's new book All That Happiness Is, which offers timeless wisdom against the grain.  Adam Gopnik has been a staff writer at The New Yorker since 1986. He is the author of numerous best-selling books, including Paris to the Moon and The Real Work: On the Mystery of Mastery. Sponor: brilliant.org/skeptic

The Future of Medicine: What You Need to Know

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