In this episode we discuss:

Why the stress caused by calorie restriction, exercise, cold thermogenesis, fasting, ketogenic diets, Wim Hoff breathing, and supplements like resveratrol is not supportive of our health


Why autophagy, mitochondrial biogenesis, and uncoupling are not always beneficial


Whether being tolerant to stress is a sign of health


Why it’s virtually impossible to apply hormesis in a practical sense


The difference between reactive oxygen species production in a high energy state versus a low energy state

 
Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy
 
Click here to check out the show notes: https://jayfeldmanwellness.com/ep-77-why-you-dont-want-to-force-autophagy-mitochondrial-biogenesis-uncoupling-hormesis-part-3/ 

 
Timestamps:
3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis
13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations
28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis  
37:05 –the difference between producing ROS in a high energy state versus a low energy state
49:16 – the low energy, high ROS state is a feature of degenerative conditions

Ep. 77: Why You DON’T Want to Force Autophagy, Mitochondrial Biogenesis, & Uncoupling (Hormesis Part 3)

Discover how you can live without constant hunger and fatigue, brain fog, poor sleep, and other low-energy symptoms. The Energy Balance Podcast will teach you how to maximize your cellular energy so you can take back your health and finally experience clear-headed focus, restful sleep, and all-day energy you didn’t think was possible.

Alternative Health

Health

Health & Fitness

In this episode we discuss:
The validity of the counterarguments against the Lipid Energy Model
Whether the Lipid Energy Model means that high LDL does not increase cardiovascular disease risk
How thyroid and metabolism relate to high LDL on a low-carb diet
What the Lean Mass Hyper-Responder phenotype means in terms of metabolic health
Whether low-carb diets are ideal for cardiovascular disease health and health in general
 
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide
 
Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/
 
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/
 
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-116-the-truth-about-ldl-and-heart-disease-lmhr-and-the-lipid-energy-model/
 

Timestamps:
0:00 – intro
1:17 – the primary counterarguments against the Lipid Energy Model 
4:15 – BMI, not saturated fat, correlates with the LMHR phenotype 
8:15 – eating carbs dramatically lowers cholesterol in LMHR 
11:14 – whether Oreos are more effective at lowering cholesterol than statins 
17:30 – high cholesterol levels in the LMHR phenotype are not due to excess saturated fat intake or cholesterol production 
19:25 – prominent cardiologists and researchers dismissing the lipid energy model due to dogmatism interferes with progress in science and medicine 
24:40 – Dr. Shawn Baker’s carbohydrate experiment and contextual considerations when reintroducing carbs into the diet 
28:46 – further support for the lipid energy model and the relationship with thyroid function 
33:32 – the difference between saturated, monounsaturated, and polyunsaturated fats in relation to lipid profiles 
34:40 – whether LDL cholesterol and ApoB cause heart disease and plaque formation 
42:18 – how the Lipid Energy Model helps uncover the underlying cause of heart disease 
45:15 – LDL levels as a marker of metabolic health rather than a cause of cardiovascular disease and why we may not always want to lower LDL 
55:02 – evidence suggesting that LDL does not drive cardiovascular disease 
1:05:43 – the difference between high LDL due to metabolic dysfunction and high LDL due to a low-carb diet 
1:09:58 – lipid values don’t tell us the whole picture: the Kitavans 
1:16:54 – why decreases in insulin, glucose, and HbA1C as well as increased lipolysis and fat oxidation on a low-carb diet is not necessarily a sign of improvement 
1:22:57 – increased lipolysis on low-carb diets does not lead to body-fat loss 
1:24:25 – whether the Lipid Energy Model proves that low-carb diets are optimal for health

Ep. 116: The TRUTH About LDL And Heart Disease: LMHR & The Lipid Energy Model

In this episode we discuss:
Whether you should be concerned about high LDL or high cholesterol on a low-carb diet 
The validity of the Lean Mass Hyper-Responder (LMHR) Phenotype and Lipid Energy Model proposed by Dave Feldman 
The metabolic state that drives the Lipid Energy Model 
How the "Lean Mass Hyper-Responder" and Lipid Energy Model support the Bioenergetic view of cardiovascular disease
 
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide
 
Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/
 
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/
 
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-115-lmhr-and-the-lipid-energy-model-implications-for-metabolism-and-hormones
 

Timestamps:
0:00 – intro
1:14 – what is the Lean Mass Hyper-Responder (LMHR) phenotype 
3:33 – how the Lipid Energy Model challenges the mainstream dogmatic view linking high cholesterol levels to heart disease
6:33 – the protective effects of cholesterol and why it does not cause heart disease, despite being necessary for atherosclerosis
9:49 – the distinction between Lean Mass Hyper-Responders and those with high cholesterol levels in the context of metabolic dysfunction
15:10 – what is the Lipid Energy Model
22:10 – how the body adapts to a lack of carbohydrates, leading to elevated cholesterol levels 
27:22 – the hormonal and metabolic state underlying the Lean Mass Hyper-Responder phenotype
32:21 – how adding carbohydrates lowers cholesterol levels in those who don't have metabolic dysfunction at a cellular level 
37:11 – whether Lean Mass Hyper-Responders are at increased risk of cardiovascular disease
42:00 – why the Lean Mass Hyper-Responder phenotype isn't ideal: stress and low thyroid function
51:10 – the parallels between the lipid energy model and physiological insulin resistance

Ep. 115: LMHR & The Lipid Energy Model: Implications For Metabolism & Hormones

In this episode we discuss:
How increasing carbohydrate intake actually improves insulin sensitivity, even in people with type 2 diabetes 
The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation 
The research showing that fatty liver disease and cardiovascular disease are both characterized by excess fatty acid oxidation 
Why strategies such as intermittent fasting, cold plunges, and OMAD (one meal a day) are not effective for improving insulin sensitivity 
 
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide
 
Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/
 
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/
 
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-114-fat-burning-drives-insulin-resistance-and-eating-carbohydrates-improves-insulin-sensitivity/
 

Timestamps:
0:00 – intro
1:17 – stress hormones (glucagon, epinephrine, and cortisol) are major contributors to insulin resistance and diabetes 
4:05 – elevated glucagon levels, not carbohydrates, are the driving force behind high fasting blood glucose levels
6:43 – glucagon is a driver of insulin resistance, while insulin is just a symptom
12:46 – the research showing that blocking stress hormones directly improves insulin sensitivity
15:14 – “hormetic” stressors like intermittent fasting, cause insulin resistance
19:30 – fat burning drives insulin resistance and keeps us in a catabolic state, driving weight gain and muscle wasting 
22:15 – cortisol drives insulin resistance and why serum cortisol levels don’t provide the full picture
25:00 – low-carb diets reduce insulin sensitivity while carbohydrate intake improves it 
29:40 – decreasing fatty acid oxidation by increasing carb intake improves our ability to tolerate carbohydrates
33:46 – burning fat contributes to increased disease processes and does not lead to losing more body fat
38:04 – fatty acid oxidation damages our mitochondria and increases fat storage
46:22 – type 2 diabetes directly contributes to heart disease by upregulating fatty acid oxidation 
52:05 – how to decrease fatty acid oxidation and improve glucose metabolism

Ep. 114: Fat-Burning Drives Insulin Resistance And Eating Carbohydrates Improves Insulin Sensitivity

In this episode we discuss:
Insulin resistance and type 2 diabetes are diseases of excess fat burning and impaired glucose metabolism
How increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes
Evidence supporting the bioenergetic view of insulin resistance and type 2 diabetes
Why carbs are not actually the cause of insulin resistance and diabetes
 
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide
 
Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/
 
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/
 
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-113-carbohydrates-dont-cause-insulin-resistance-or-diabetes-evidence-for-the-bioenergetic-view
 

Timestamps:
0:00 – intro
1:28 – what the mainstream view of insulin resistance gets wrong when it comes to what causes insulin resistance and diabetes
3:24 – glycolysis and fat oxidation are favored, and glucose oxidation is inhibited in insulin resistance and diabetes
8:39 – what happens to glucose in diabetic cells
10:32 – why insulin resistance is a symptom rather than the driver of diabetes
12:55 – research showing that insulin resistance is driven by poor glucose metabolism
20:50 – impaired glucose uptake is not caused by excess insulin; fat-burning and impaired glucose metabolism are the culprits 
27:10 – the problems with relying on fat oxidation over carbohydrate oxidation 
30:43 – how increasing blood glucose levels or increasing insulin can restore normal glucose uptake in diabetes
35:28 – how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones
37:16 - why fatty acid oxidation is NOT the underlying cause of insulin resistance
40:06 – factors that support or block mitochondrial respiration
41:20 – how excess fatty acid oxidation contributes to the pathology of insulin resistance and can impair glucose metabolism over time
42:49 - how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones (cont.)
47:08 – why we don’t want to blame insulin for insulin resistance and what really causes high fasting blood glucose
49:22 – how low-carb diets increase stress hormones and decrease insulin sensitivity

Ep. 113: Carbohydrates Don’t Cause Insulin Resistance or Diabetes; Evidence For The Bioenergetic View

In this episode we discuss:
Why you might want to think twice about using resistant starch for blood sugar regulation and gut health
Ways to increase or reduce the amount of resistant starch in the foods you eat 
How to tell if resistant starch is negatively impacting your gut health, and why non-resistant starch may also pose a problem
The optimal calcium to phosphorus ratio according to the research
The calcium paradox and why calcium intake doesn’t increase excitation or calcification
The hidden dangers of excess phosphorus intake 
 
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide
 
Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/
 
Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/
 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/
 
Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-112-the-problems-with-resistant-starch-and-balancing-the-calcium-to-phosphorus-ratio-qa
 

Timestamps:
0:00 – intro
1:00 – mainstream health claims about resistant starch and why we disagree
6:15 – whether there are any benefits to including resistant starch in your diet
11:07 – how to tell if resistant starch is negatively impacting your gut health and how to avoid it
16:05 – which starches are easiest to digest and the factors that affect our ability to digest starches optimally
21:38 – why we should pay attention to our calcium to phosphorus ratio and the risks of high parathyroid hormone levels
26:19 – the optimal calcium to phosphorus ratio and the calcium paradox in terms of regulating blood pressure 
31:21 – which phosphorus-containing foods we should avoid to optimize bone density 
34:36 – the calcium paradox and why consuming calcium doesn’t increase intracellular calcium

Ep. 77: Why You DON’T Want to Force Autophagy, Mitochondrial Biogenesis, & Uncoupling (Hormesis Part 3)

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