December 03, 2025

#838: The Random Show — The 2–2–2 Rule, The Future of AI, Bioelectric Medicine, Surviving Modern Dating, The Promises of DORAs for Alzheimer’s, and Wisdom from Anthony de Mello

1 hour 51 minutes

Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose (digg.com)!

This episode is brought to you by:

Qlosi prescription eye drop used to treat age-related blurry near vision (presbyopia) in adults: https://Qlosi.com/Tim

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Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $400 off your very own Pod 5 Ultra)

Coyote the card game, which I co-created with Exploding Kittens: https://coyotegame.com

Timestamps:

[00:00:00] Start.
[00:00:52] Why Kevin concluded nearly seven months of sobriety, and the 2-2-2 Rule he now follows for alcohol consumption.
[00:07:12] My recent adventures in accelerated TMS and bioelectric medicine.
[00:21:09] The tragic death of Nolan Williams and funding future research through the Saisei Foundation.
[00:24:23] Aphantasia vs. hyperphantasia, and Joshua Waitzkin's ability to "feel" chess.
[00:33:12] DORAs for sleep and Alzheimer's prevention: Matt Walker, Belsomra, and the terrifying p-tau blood test.
[00:41:21] Dale Bredesen's kitchen-sink approach to dementia and the ketogenic connection.
[00:46:22] The rapid pace of AI development: Why your opinion from three months ago is already obsolete.
[00:49:40] Google's full-stack advantage: TPUs, Gemini 3, and why they were built for this moment.
[00:52:50] The future of venture capital: Seed rounds shift later as entrepreneurs gain leverage.
[00:58:05] Kevin's three AI investment buckets: Power, data centers, and bloated companies ripe for automation.
[01:02:05] Holiday gift ideas and recommended reading.
[01:17:41] The Way App and meditation with Zen master Henry Shukman.
[01:21:44] Kevin's AI stack: Nothing earbuds, Sandbar ring, Notion AI, and the NotebookLM podcast hack.
[01:26:58] Oboe.fyi: The AI learning platform and my investment philosophy.
[01:32:09] My new girlfriend, the perils of modern dating apps, and building a communication toolkit.
[01:38:17] Terry Real's relationship wisdom: Why objective reality has no place in an argument.
[01:47:18] Dog updates: Molly, a new puppy, and Toaster on rapamycin.
[01:47:58] Parting thoughts and happy holidays.

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By Tim Ferriss: Bestselling Author, Human Guinea Pig

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