The Louisville Cardinals face their first ACC test against Pittsburgh, with key players questionable due to injuries. Jeff Brohm's team aims to silence doubters and set the tone for conference play. Miller Moss and the offense face their toughest challenge yet against Pitt's disruptive defense, averaging 4 sacks per game. Host Dalton Pence breaks down the keys to victory, emphasizing the need to establish the run and protect Moss. On defense, the Cardinals must contain Eli Holstein and limit big plays from Pitt's explosive passing attack. With ACC Championship implications on the line, can Louisville overcome injuries and secure a crucial road win? Tune in for expert analysis on this pivotal matchup and discover if the Cardinals can remain unbeaten in 2025.

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