06.25.2017 - By Roman Cheplyaka
I talk about allele-specific expression: why it arises and how it can be
reliably detected.
Sections:
The biology of allele-specific expression (2:17)
Detecting allele-specific expression with RNA-seq (7:46)
Mapping and sequencing biases (16:39)
The experiment in yeast (19:47)
Statistical models (21:44)
Links:
A powerful and flexible statistical framework for testing hypotheses of
allele-specific gene expression from RNA-seq data
Supplemenal information
Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data
The talk by John Marioni
The blog post explaining the RSEM model
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