Antipsychotic medications are the cornerstone of treatment for schizophrenia and other thought disorders, but their use requires careful nursing oversight. In this episode, we’ll unpack the classifications of antipsychotics, comparing typical (first-generation) and atypical (second-generation) agents, and explain their mechanisms of action—primarily through dopamine and serotonin receptor blockade. We’ll discuss key prototypes, including Chlorpromazine, Haloperidol, and Clozapine, while highlighting the goals of therapy, from short-term symptom relief to long-term functional recovery. Special attention will be given to the adverse effects of these drugs, including extrapyramidal symptoms such as acute dystonia, akathisia, parkinsonism, and tardive dyskinesia, along with life-threatening complications like anticholinergic crisis and neuroleptic malignant syndrome. Throughout, we’ll emphasize the nurse’s vital role in monitoring, early recognition, patient education, and intervention, ensuring safe and effective use of these powerful medications.