Base editing is a technique for substituting the building blocks of DNA. It has only been around for a few years, so its use to apparently cure cancer was all the more remarkable, as BBC Health Correspondent James Gallagher tells us. We take a trip down the river Wye with ecologist Steve Ormerod who tells us why the river is a microcosm for some of the global issues being discussed at the UN Biodiversity summit in Montreal. BBC Environment Correspondent Victoria Gill gives us the latest on the state of negotiations there. And the current surge in infections associated with the streptococcus bacteria has led to deaths in a few cases. It is usually a seasonal infection, worse in the spring. We ask microbiologist Dr Claire Turner from Sheffield University why we seem to be seeing a surge of infections now and her research on strep vaccine targets. BBC Inside Science is produced in collaboration with the Open University.

Cancer cure, Strep A research and hopes for biodiversity

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Professor and presenter, Chris Lintott, talks about his new book Our Accidental Universe; a tour of chance encounters and human error in pursuit of asteroids, pulsars, radio waves, new stars and alien life. Even with incredible technological developments, the major astronomical events of the past century are largely down to plain ol’ good luck; discovered not, as you might assume, by careful experiment, but as surprises when we have been looking for something else entirely. For instance, the most promising habitat for life beyond Earth turns out to be Saturn's tiny moon Enceladus, whose oceans were revealed when NASA's Cassini probe did a drive-by and, we get the most from the Hubble Space Telescope by pointing it at absolutely nothing!  A new company has launched which aims to mine Helium-3 on the moon to sell on Earth. This rare isotope is used for supercooling quantum computers and some scientists dream of using it in nuclear fusion as a new source of renewable energy. But is this ambition realistic and, if so, could it be within reach anytime soon? Planetary scientist Sara Russell of the Natural History Museum explains all.  There are many moons in our solar systems, but one of the strangest is Titan; the largest moon of the Saturn system. It gets colder than 100 degrees Celsius and has a thick atmosphere that creates weather. But its biggest mystery is the enormous, coffee-coloured dunes that cover a large part of its surface. Where did they come from? Planetary scientist Bill Bottke has a cunning theory.  In our universe, some stars are twins. They originate from the same molecular clouds and should be identical, but some pairs are not as similar as you’d expect. Marnie speaks to astrophysicist Yuan-Sen Ting about his new paper which illuminates how this difference might occur. His theory is that one of the stars, perhaps the evil twin, has been busy eating up vulnerable planets...  
 
Presenter: Marnie Chesterton 
Producers: Louise Orchard, Florian Bohr and Imaan Moin 
Editor: Martin Smith 
Production Co-ordinator: Jana Bennett-Holesworth   BBC Inside Science is produced in collaboration with the Open University.

Our Accidental Universe

The world’s oldest fossilised forest was uncovered in Somerset last week. We head to palaeobotanist, Dr Christopher Berry’s, lab at Cardiff University to learn about these cladoxylopsids. They lived 390 million years ago and although they are not the ancestors of today’s trees, they reveal some extraordinary evolutionary secrets.  Also, Marnie speaks to Dr Chris Thorogood of the University of Oxford Botanic Gardens about his new book Pathless Forest: The Quest to Save the World’s Largest Flowers. Called “Rafflesia” plants and found in the remotest parts of South East Asia, their flowers burst from the rain forest floor the size of pumpkins and are critically endangered.  Chris talks of his world of extreme fieldwork and hair-raising expeditions, braving leeches, lizards and lethal forest swamps, to discover the rarest of rare blooms.  Plus, the Wildlife Trust’s Making Friends with Molluscs campaign starts today, and I’m sure many gardeners will declare this an impossible task! We visit some allotments in Bristol to find out how people are managing slug and snail populations. And chat to Brian Eversham from the Trust of Bedfordshire, Cambridgeshire and Northamptonshire, who explains why these garden creatures should be considered our friends, not foes.    And finally, Dr Stewart Husband from last week’s programme returns to answer more of your burning questions about your tap water.

World’s oldest forest fossils

A recent study on how to get rid of microplastics in water sparked presenter Marnie Chesterton’s curiosity. When she turns on the tap in her kitchen each day, what comes out is drinkable, clean water. But where did it come from, and what’s in it? Dr Stewart Husband from Sheffield University answers this and more, including listener questions from around the UK. Is water sterile? Should I use a filter? And why does my water smell like chlorine?  Also, new research indicates that bumblebees can show each other how to solve puzzles too complex for them to learn on their own. Professor Lars Chittka put these clever insects to the test and found that they could learn through social interaction. How exactly did the experiment work, and what does this mean for our understanding of social insects? Reporter Hannah Fisher visits the bee lab at Queen Mary University in London.   And finally, more than 20 million years ago, our branch of the tree of life lost its tail. At that point in time, apes split from another animal group, monkeys. Now, geneticist Dr Bo Xia at the Broad Institute of MIT and Harvard thinks he may have found the specific mutation that took our tails. Marnie speaks with evolutionary biologist Dr Tom Stubbs from the Open University about why being tail-less could be beneficial. What would a hypothetical parallel universe look like where humans roam the earth, tails intact? And what would these tails look like?  Presenter: Marnie Chesterton 
Producers: Louise Orchard, Florian Bohr, Jonathan Blackwell, Imaan Moin 
Editor: Martin Smith 
Production Co-ordinator: Jana Bennett-Holesworth   BBC Inside Science is produced in collaboration with the Open University.

How pure is the water from your tap?

Switzerland has submitted a proposal to create a United Nations expert group on solar geoengineering to inform governments and stakeholders. The idea was discussed at the UN Environment Assembly in Nairobi, Kenya, this week. Professor Aarti Gupta shares how, after tense negotiations, the different member states could not agree, and the proposal was withdrawn. Why is solar geoengineering a controversial issue? How would dimming the sun even work? And should we consider it a genuine option in our fight against climate change? Dr Pete Irvine and Professor Joanna Haigh join presenter Marnie Chesterton in the studio to discuss.   Animal welfare charities have been celebrating a ban on donkey skin trade, agreed to this month by 55 African countries. This will make it illegal to slaughter donkeys for their skin across the continent, where around two thirds of the world’s 53 million donkeys live. Victoria Gill tells Marnie that the demand for the animals' skins is fuelled by the popularity of an ancient Chinese medicine called Ejiao, believed to have health-enhancing and youth-preserving properties and traditionally made from donkey hides.  Lastly, Dr Jess Wade, physicist and science communicator at Imperial College London, discusses Breaking Through: My Life in Science. It’s the memoir of Nobel Prize-winning biochemist Dr Katalin Karikó, whose passion and dedication to mRNA research led to the development of the life-changing COVID mRNA vaccines.  Presenter: Marnie Chesterton 
Producers: Florian Bohr, Louise Orchard 
Assistant Producer: Imaan Moin 
Editor: Martin Smith 
Production Co-ordinator: Jana Bennett-Holesworth BBC Inside Science is produced in collaboration with the Open University.

Dimming the Sun

Professor Ben Garrod guest presents.  As a new 'meaty rice' is created and Fortnum & Mason launch a scotch egg made with cultivated meat that they hope to have on sale as early as next year, we investigate the world of laboratory-grown meat.   Mark Post made the first ever synthetic meat in 2012 to the tune of £200,000. He tells us how these lab-grown meats are made and how, he thinks, they could play an important role in reducing greenhouse gas emissions and feeding a growing population. Jenny Kleeman, author of Sex, Robots and Vegan Meat, is more sceptical, citing concerns over food security and if the public really want to eat this stuff.   A stingray called Charlotte has become pregnant, despite there being no other stingrays in her tank at the Aquarium & Shark Lab in North Carolina. Marine biologist Dr Helen Scales considers how this may have happened.  And cosmic minerologist Sara Russell from the Natural History Museum tells us how astronomers tracked and found a particularly unusual asteroid entering Earth’s atmosphere and what we might learn from it.   Presenter: Professor Ben Garrod 
Producers: Hannah Robins, Florian Bohr, Alice Lipscombe-Southwell and Jonathan Blackwell 
Editor: Martin Smith 
Production Co-ordinator: Jana Bennett-Holesworth   BBC Inside Science is produced in collaboration with the Open University.

Cancer cure, Strep A research and hopes for biodiversity

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