UTHSC PA Program Podcast

Cardiovascular - Carotid Artery Disease


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In this episode, we review carotid artery disease, a major cause of ischemic stroke resulting from atherosclerotic narrowing of the carotid arteries. We break down the pathophysiology of plaque buildup, luminal stenosis, and embolization, and discuss key risk factors including hypertension, hyperlipidemia, smoking, diabetes, and advanced age. The episode highlights the often silent progression of disease and classic warning signs such as transient ischemic attacks (TIAs), amaurosis fugax, and focal neurologic deficits. We also cover essential diagnostic approaches, including carotid duplex ultrasound as the first-line test, and review management strategies ranging from aggressive medical therapy to procedural interventions like carotid endarterectomy and stenting for high-risk patients.

References

  1. Bushardt RL, Colomb-Lippa DM, Klinger AM, Reed H. The JAAPA QRS Review for PAs: Study Plan and Guide for PANCE and PANRE. 1st ed. LWW; 2021. ISBN: 9781975143817.
  2. Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association Stroke. 2021; 52(7).
  3. Naylor AR. Time to rethink management strategies in asymptomatic carotid artery disease. Nat Rev Cardiol. 2011 Oct 11;9(2):116-24. doi: 10.1038/nrcardio.2011.151. PMID: 21989048.
  4. Brott TG, Howard G, Lal BK, et al. Medical Management and Revascularization for Asymptomatic Carotid Stenosis N Engl J Med. 2026; 394(3):219-231.
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UTHSC PA Program PodcastBy Kristopher Maday, PA-C, DFAAPA