Is psilocybin a potential treatment for major depression? There's certainly been a lot of press coverage, but to date, the reports are largely open trials in a variety of conditions, including OCD, substance use, PTSD, and patients with cancer and psychological distress. Against that backdrop, a randomized trial of psilocybin for major depression is an exciting new step.

Faculty: Jim Phelps, M.D. Hosts: Jessica Diaz, M.D.; Flavio Guzman, M.D.

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• Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial