EMCrit 266 – High Sensitivity Troponins with Louise Cullen

Today on the podcast we discuss High Sensitivity Troponins with Dr. Louise Cullen...

Professor Louise Cullen

Louise Cullen is a Senior Staff Specialist in the Department of Emergency Medicine, Royal Brisbane and Women’s Hospital, and an active clinician-researcher with particular interests in acute cardiac diseases, syncope, and cardiac biomarkers. She is widely published in numerous peer-reviewed journal including the Lancet. Her mantra is that “You do not do research for research sake” and as such, clinical redesign and translational research is a key part of her endeavours.

 COI

Dr. Cullen reports receiving grants from Roche; grants, consultancy fees, and personal fees from Abbott Diagnostics; personal fees from AstraZeneca; and personal fees from Novartis outside of the submitted work.

We have resolved these conflicts by:

1. Not speaking of any individual manufacturer's assays

2. In the US, the manufacturers are eliminating prior assays, thereby obviating the conflict of discussing hsTN (i.e. there will be no purchasing decision on your part--you're getting 'em whether you like it or not)

High Sensitivity Troponins

IFCC has released a lab spec sheet on troponins

Troponin values must be individualized based on your hospital's assay

ACS Decision Aides

* IMPACT Trial

* Comparison of four decision aids for the early diagnosis of acute coronary syndromes in the emergency department

* MDCalc TMACs

* MDCALC EDAC

* HsTNi with decision rules

Other FOAM

* EM Topics

* Hennepin High-Sens Troponin Algorithm

Now on to the Podcast...