EA Forum Podcast (All audio)

“Emerging evidence on treating cluster headaches with DMT” by Alfredo Parra 🔸, Curran Janssens, algekalipso


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DMT, the smallest microdose of maybe 5mg with a vape pen stops the worst pain known, in literally 10–20 seconds. Acid and mushrooms as well, but they take time to come up. Even the smallest sub-perceptual dose of DMT stops the pain.

- Yiftach Yerushalmy, cluster headache patient

One inhalation [of DMT] will end the attack for most people. Everybody is reporting the exact same thing. […] It could end that attack in less than a minute. […] You can take one inhalation, you can wait 30 seconds, and if that cluster is not gone completely, then you know it's time to take another inhalation. You don't have to wait 2h into a psilocybin trip.

- Bob Wold, president of Clusterbusters and cluster headache patient

I use the word game changer because a lot of times our attacks will come at night after we go to sleep. [...]

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Outline:

(03:14) How DMT is used for cluster headaches

(07:57) The evidence

(12:10) How and why would DMT work to treat cluster headaches?

(14:06) Challenges

(16:03) What is needed next

(18:24) Appendix: Bob Wold's Pocket Guide to Cluster Headaches: DMT

(21:18) DMT Vape pens and cartridges. For use in treating cluster headaches.

(21:25) Cartridges

(25:13) Inhalations

(31:06) DMT - Alternative Source - Delivery System

(32:07) General notes on psychedelic treatments

(33:25) When to begin dosing with psychedelics

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First published:

October 18th, 2025

Source:

https://forum.effectivealtruism.org/posts/x8P8EGnujSZm6fyMH/emerging-evidence-on-treating-cluster-headaches-with-dmt

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Narrated by TYPE III AUDIO.

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EA Forum Podcast (All audio)By EA Forum Team