In this episode of The Leather Lounge, host Sean Longstreet sits down with Jonathan Sadlowe, co-founder of Signal21 — a powerful analytics platform purpose-built for the Bitcoin and Stacks ecosystems.As Bitcoin-native DeFi gains momentum, it’s becoming harder to keep track of what’s actually happening on-chain. Signal21 is stepping in to provide real-time visibility, surfacing key insights about wallet growth, TVL, developer activity, and broader trends across Bitcoin Layer 2s.Jonathan brings a rare blend of technical precision and forward-thinking vision. In this conversation, he shares his journey into Bitcoin, walks through a live demo of Signal21, and offers deep insights into the next wave of blockchain innovation — from sBTC adoption and RWA integrations to e-commerce, healthcare, and even AI.This episode is a must-watch for developers, investors, and anyone curious about how analytics is becoming essential infrastructure for the Bitcoin economy.03:07 Jonathan Sadlow's Background and Journey into Bitcoin07:02 Evolution of the Bitcoin Ecosystem and Stacks08:29 Stacks is Winning in the Bitcoin L2 Landscape10:23 Comprehensive Demo of Signal 21 17:52 More Use Cases for Signal 2120:51 Current Trends: Bitcoin Yield and Treasury Companies23:58 The Potential Unwind of the Bitcoin Treasury Companies25:37 sBTC, DeFi, Healthcare, insurance, and RWA's on Bitcoin via Stacks28:37 E-Commerce will be a Gamer-Changer32:17 The Problem with Stable Coins and the Need for Market Structure34:08 Thoughts on AI and Healthcare Innovations38:22 It's a great time to be building in Bitcoin

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