In this week's episode, we turn our focus to mitragynine and 7-hydroxymitragynine, the primary active components of kratom. We explore what these alkaloids are, how they behave post-mortem, and what we know about their stability in biological matrices. We also discuss the evidence around 7-hydroxymitragynine’s role in respiratory depression, and the growing concern around kratom products in the U.S. that contain 7-hydroxymitragynine as their primary compound. Join us as we unpack the complexities surrounding these substances and their implications for toxicologists.

Hope you enjoy!

Links to papers we discussed:

https://academic.oup.com/jat/article-abstract/49/2/122/7934595?redirectedFrom=fulltext

https://pmc.ncbi.nlm.nih.gov/articles/PMC9314834/

https://www.cfsre.org/images/content/reports/public_alerts/7-Hydroxy_Mitragynine_NPS_Discovery_033125.pdf

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