Nobel Prize winning chemist Frances Arnold left home at 15 and went to school ‘only when she felt like it’. She disagreed with her parents about the Vietnam war and drove big yellow taxis in Pittsburgh to pay the rent.
Decades later, after several changes of direction (from aerospace engineer to bio-tech pioneer), she invented a radical new approach to engineering enzymes. Rather than try to design industrial enzymes from scratch (which she considered to be an impossible task), Frances decided to let Nature do the work. ‘I breed enzymes like other people breed cats and dogs’ she says. While some colleagues accused her of intellectual laziness, industry jumped on her ideas and used them in the manufacture of everything from laundry detergents to pharmaceuticals.
She talks to Jim Al-Khalili about her journey from taxi driver to Nobel Prize, personal tragedy mid-life and why advising the White House is much harder than doing scientific research.

Frances Arnold

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Professor Ben Garrod and Dr Jess French get under the skin (and blubber) of the California sea lion, to crack the key to its success both on land and at sea. Its ability to dive hundreds of meters down, keep warm in icy waters, and run on land, can all be explained through its unique internal anatomy. They are joined by zookeeper and sea lion trainer Mae Betts, who adds insight into the intelligence of these sleek marine mammals. Co-Presenters: Ben Garrod and Jess French
Executive Producer: Adrian Washbourne
Producer: Ella Hubber
Editor: Martin Smith
Production Co-ordinator: Jana Bennett-Holesworth

Wild Inside: The Sea Lion

The tiny sap-sucking aphid, at just a few millimetres long, is the scourge of many gardeners and crop-growers worldwide, spreading astonishingly rapidly and inflicting huge damage as it seeks to outwit many host plants’ natural defences. With insights and guidance from aphid expert George Seddon-Roberts at the John Innes Centre, Norwich, some delicate dissecting tools, and a state of the art microscope, Professor Ben Garrod and Dr Jess French delve inside this herbivorous insect to unravel the anatomy and physiology that’s secured its extraordinary reproductive success, whilst offering new clues as to how we could curtail its damaging impact in the future. Co-Presenters: Ben Garrod and Jess French
Executive Producer: Adrian Washbourne
Producer: Ella Hubber
Editor: Martin Smith
Production Co-ordinator: Jana Bennett-Holesworth

Wild Inside: The Aphid

Ominously called the lamb vulture, there are many myths and misconceptions surrounding the bearded vulture. Flying the mountainous ranges across central Asia and eastern Africa, with a wingspan of almost three meters, the bearded vulture is am impressive Old World vulture. Prof Ben Garrod and Dr Jess French are looking past the beautifully coloured plumage, and delving deep inside to learn what this bird of prey really eats and what keeps its great wings aloft.

Wild Inside: The Bearded Vulture

Wild Inside returns for a new series to take a look at some of our planet’s most exceptional and unusual creatures from an entirely new perspective: the inside. Whilst we can learn a lot from observing the outside, the secrets to the success of any animal – whether they swim, fly, or hop – lies in their complex internal anatomy. How do these wild animals survive and thrive in harsh and changing environments? To truly understand we need to delve inside. Professor Ben Garrod, evolutionary biologist from the University of East Anglia, and expert veterinary surgeon Dr Jess French, open up and investigate what makes each of these animals unique, in terms of their extraordinary anatomy, behaviour and their evolutionary history. Along the way, they reveal some unique adaptations which give each species a leg (or claw) up in surviving in the big, wild world. The series begins with an icon of the outback – known best for its hopping, boxing, and cosy pouch – the red kangaroo. Despite the immense heat and lack of water, these marsupials dominate Australia, with their evolutionary history driving them to success. From the powerful legs which allow them to hop up to 40km an hour, to an unexpected reproductive system that keeps their populations plentiful, Ben, Jess and marsupial expert Dr Jack Ashby reveal a mammalian anatomy which holds many surprises.

Wild Inside: The Red Kangaroo

Hannah Fry explores two tales of data and discovery. A young researcher gains access to a secretive data set and discovers a system causing harm to the very people it is supposed to help.  One day a student makes a discovery which, if true, could shake the intellectual foundations of a global movement, and undermine politicians around the world. Producer: Lauren Armstrong Carter

Frances Arnold

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