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Gastrointestinal - Acute Pancreatitis
In this episode, we break down acute pancreatitis, a common and potentially life-threatening cause of acute abdominal pain. We review the pathophysiology of premature enzyme activation leading to pancreatic autodigestion and systemic inflammation, along with key risk factors including gallstones, alcohol use, and hypertriglyceridemia. The discussion highlights diagnostic criteria, appropriate imaging selection, early aggressive fluid resuscitation, and complication recognition. Emphasis is placed on the critical first 24–48 hours and the importance of identifying and treating the underlying cause to prevent recurrence.
References
1) Bushardt RL, Colomb-Lippa DM, Klinger AM, Reed H. The JAAPA QRS Review for PAs: Study Plan and Guide for PANCE and PANRE. 1st ed. LWW; 2021. ISBN: 9781975143817.
2) Mederos MA, Reber HA, Girgis MD. Acute Pancreatitis: A Review. JAMA. 2021;325(4):382–390. doi:10.1001/jama.2020.20317
3) Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med 2016;375:1972-1981. DOI: 10.1056/NEJMra1505202
4) Szatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, Beyer G, Sutton R. Acute Pancreatitis: Diagnosis and Treatment. Drugs. 2022 Aug;82(12):1251-1276. doi: 10.1007/s40265-022-01766-4. Epub 2022 Sep 8. PMID: 36074322; PMCID: PMC9454414.
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By Kristopher Maday, PA-C, DFAAPAIn this episode, we break down acute pancreatitis, a common and potentially life-threatening cause of acute abdominal pain. We review the pathophysiology of premature enzyme activation leading to pancreatic autodigestion and systemic inflammation, along with key risk factors including gallstones, alcohol use, and hypertriglyceridemia. The discussion highlights diagnostic criteria, appropriate imaging selection, early aggressive fluid resuscitation, and complication recognition. Emphasis is placed on the critical first 24–48 hours and the importance of identifying and treating the underlying cause to prevent recurrence.
References
1) Bushardt RL, Colomb-Lippa DM, Klinger AM, Reed H. The JAAPA QRS Review for PAs: Study Plan and Guide for PANCE and PANRE. 1st ed. LWW; 2021. ISBN: 9781975143817.
2) Mederos MA, Reber HA, Girgis MD. Acute Pancreatitis: A Review. JAMA. 2021;325(4):382–390. doi:10.1001/jama.2020.20317
3) Forsmark CE, Vege SS, Wilcox CM. Acute Pancreatitis. N Engl J Med 2016;375:1972-1981. DOI: 10.1056/NEJMra1505202
4) Szatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, Beyer G, Sutton R. Acute Pancreatitis: Diagnosis and Treatment. Drugs. 2022 Aug;82(12):1251-1276. doi: 10.1007/s40265-022-01766-4. Epub 2022 Sep 8. PMID: 36074322; PMCID: PMC9454414.