According to the CDC, 6 in 10 adults in the U.S. have a chronic disease like cancer or diabetes. Meanwhile, the process for discovering new drug treatments is critically expensive and inefficient. About 90% of drug candidates fail to gain FDA approval; the average cost to develop a new drug is over $1 billion; and testing can take over 10 years.




Noam Solomon is on a mission to change this. His company, Immunai, is using artificial intelligence to create an atlas of the human immune system. 




This week on How I Built This Lab, Guy talks with Noam about how Immunai’s immune system mapping is accelerating the development of new personalized drug therapies. Plus, Noam shares how Immunai’s culture of ‘not knowing’ drives scientific innovation. 

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HIBT Lab! Immunai: Noam Solomon

Guy Raz interviews the world’s best-known entrepreneurs to learn how they built their iconic brands. In each episode, founders reveal deep, intimate moments of doubt and failure, and share insights on their eventual success.&nbsp;How I Built This&nbsp;is a master-class on innovation, creativity, leadership and how to navigate challenges of all kinds. New episodes on Mondays and Thursdays for free. Listen 1-week early and to all episodes ad-free with Wondery+ or Amazon Music with a Prime membership or Amazon Music Unlimited subscription. Get your How I Built This merch at WonderyShop.com/HowIBuiltThis 


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With over 14.5 million subscribers, Rosanna Pansino has one of the most popular baking channels on YouTube But she never would have imagined her success back in 2010 when she started making videos as a hobby. At the time, she was a working actor in Hollywood with dreams of landing a leading role, but after receiving an ultimatum from her agent, she was forced to choose between a career in traditional television or the nascent digital world of YouTube. More than a decade after her fateful choice, Rosanna has come full circle with her dreams in entertainment as she hosts her own shows on The Food Network — while continuing to post on YouTube and adding to her catalog of over 1,400 videos with more than 4.7 billion views.




This episode was produced by Carla Esteves, with music by Ramtin Arablouei

Edited by Neva Grant and Casey Herman, with research help from Melia Agudelo.




You can follow HIBT on X & Instagram, and email us at hibt@id.wondery.com.

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YouTube Creator and Cookbook Author: Rosanna Pansino

Growing up, Danielle Walker’s family often convened for big meals prepared by her Italian grandmother, Grandma Marge. Back then, Danielle enjoyed a wide variety of food without restriction; but she began experiencing severe abdominal pain in her 20s that ultimately led her to totally transform her diet—cutting grains, lactose, sugar and more. 

As Danielle found relief in this approach—and realized that others with similar ailments could as well—she began compiling her recipes in an online blog called Against All Grain. Before long, the self-taught chef became a bestselling cookbook author, more recently branching out with her own product lines and cooking courses. 

This week on How I Built This Lab, Danielle talks with Guy about being an ‘accidental entrepreneur’ as she chronicles her journey to building a multifaceted business centered around healthy eating. Plus, Danielle shares her advice for other creators looking to build an audience and discusses food’s potential to help millions suffering from autoimmune diseases.

This episode was produced by Katherine Sypher with music composed by Ramtin Arablouei. It was edited by John Isabella with research help from Sam Paulson. Our audio engineer was Robert Rodriguez.

You can follow HIBT on X & Instagram, and email us at hibt@id.wondery.com.

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Healing through food with Danielle Walker of Against All Grain (2022)

As one of the most successful creators on YouTube, Mark Rober doesn’t see what he does as a business. Instead, it’s a way to celebrate science in the most joyful way possible. While working as an engineer at NASA, he made his YouTube debut with a tutorial on how to make a gory Halloween costume with two iPads and a lot of duct tape. Over time, his videos became more elaborate, including a belly flop into a pool full of Jello, and a demo of a glitter-fart bomb to get revenge on porch pirates. Within a few years, Mark was teaching online science classes and selling subscription boxes for kids. Today, his YouTube channel has 5.5 billion views, 48 million subscribers…and–astonishingly, given that audience–less than 150 videos. 




This episode was produced by J.C. Howard, with music by Ramtin Arablouei

Edited by Neva Grant, with research help from Sam Paulson.




You can follow HIBT on Twitter & Instagram, and email us at hibt@id.wondery.com.

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CrunchLabs: Mark Rober

For decades, Shane Legg has anticipated the arrival of “artificial general intelligence” or AGI. 

In other words: an artificial agent that can do all the kinds of cognitive tasks that people can typically do, and possibly more...

Now as the Chief AGI Scientist and a co-founder of Google DeepMind, he stands by that prediction and is calling on the world to prepare. 

This week on How I Built This Lab, Shane’s path to becoming an early AI expert and the work he and his team are doing to prepare for the technological revolution ahead. 




This episode was produced by Sam Paulson with music composed by Ramtin Arablouei. It was edited by John Isabella with research help from Carla Esteves. Our audio engineer was Cena Loffredo.

You can follow HIBT on X & Instagram, and email us at hibt@id.wondery.com.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

AI is smarter than you think with Shane Legg of Google DeepMind

Best friends Rhett McLaughlin and Link Neal started out as “comedians for Christ,” and grew their partnership into one of the most successful YouTube platforms in existence. During college they created silly videos and songs for Christian events, and later built a following on YouTube before most people knew what it was. After struggling to find stardom in Hollywood, they continued to build a presence on YouTube: sampling punishingly hot peppers, writing ear-wormy songs about random things, showing off glasses that turned the world upside down. Nowadays, their entertainment company, Mythical, reports over 75 million subscribers and 25 billion lifetime views.

This episode was produced and researched by Katherine Sypher with music composed by Ramtin Arablouei.

It was edited by Neva Grant.

You can follow HIBT on Twitter & Instagram, and email us at hibt@id.wondery.com.

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

HIBT Lab! Immunai: Noam Solomon

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