How Do Antidepressants Work, Genetic Testing For Depression. Sept 16, 2022, Part 1

Why The Owner of Patagonia Gave Away The Whole Company

Earlier this week, the founder and owner of Patagonia Yvon Chouinard—the company known for their famous puffer jackets and outdoor gear—gave away the whole company. Who’d he give it to? The Earth.

“Hopefully this will influence a new form of capitalism that doesn’t end up with a few rich people and a bunch of poor people,” Chouinard told David Gelles for The New York Times. “We are going to give away the maximum amount of money to people who are actively working on saving this planet.”

Purbita Saha, deputy editor at Popular Science, debriefs Ira on Chouinard’s decision, as well as other science stories of the week. They talk about if it’s safe to get the COVID booster and flu shot at the same time, how a new blood test could catch early stages of cancer, why the night sky is bluer, the reason why NASA is crashing a spacecraft into an asteroid, and the fight over trash between cockatoos and Australians.

Depression Isn’t Caused By Low Serotonin. So How Do Antidepressants Work?

In 2001, a now classic Zoloft commercial hit the airwaves—featuring a sad little blob with a rain cloud following it around. The commercial explains that “while the cause is unknown, depression may be related to an imbalance of natural chemicals between nerve cells in the brain. Prescription Zoloft works to correct this imbalance.”

That theory of depression as a chemical imbalance is based on a simple premise: Depressed people’s brains lack serotonin. If a patient takes a serotonin reuptake inhibitor (SSRI), like Prozac or Zoloft, it boosts their serotonin levels, and their depression lifts. The trouble is that when researchers started testing this theory they found it didn’t hold up. Serotonin is certainly involved in depression. But it’s way more complicated than it originally seemed.To be clear, there is a body of research showing that antidepressants do work—it’s just unclear exactly how they work.

Read the rest at sciencefriday.com.

Understanding Metabolism Genes Might Improve Depression Treatment

Sometimes finding the right antidepressant medication is basically trial and error. Scientists are still trying to figure out why some antidepressants work for some people, but not others. Researchers at the Veterans Administration wanted to know if genetic testing might help doctors with prescribing the antidepressant best suited for their patients. Specifically, they examined genes that indicate whether or not someone is able to properly metabolize a medication.

Ira is joined by Dr. David Oslin, professor of psychiatry at the Crescenz Department of Veterans Affairs Medical Center and University of Pennsylvania Perelman School of Medicine, to explain his latest research and its broader implications.

Transcripts for each segment will be available the week after the show airs on sciencefriday.com.