#hvac #pharmaceutical

HVAC fundamental design for Pharmaceutical production.

Main design points to follow

The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications

Hvac can control air born dust, mirco organism, skin flakes, infiltration & hair.

Hvac maintains  positive air pressure in the fabrication laboratory (clean room).

Hvac maintains more positive pressure than the adjoining less critical rooms.

Hvac Maintains 50% Relative humidity and require clean Room temperature.

Fabrication lab walls should be all sealed from penetrations, electrical cables, ducts etc...

Cooling load is from Lighting, equipment, personnel & partitions.

Air shower rooms at the entrance of the clean rooms.

Ducts sealed with silicon, no acoustic lining & rubber gaskets.

Hard surfaces with non porous materials, walls, floors etc...

Clean rooms are classified between Class 100 to class 100,000 in Pharma.

Examples: Tableting class 100k, oral product class 10k, Injectable products class 100.

Critical areas not less than class 100. Maybe even less standards now with Covid-19.

Airflow to be laminar at 90 FPM and pressurisation of 0.05"WG.

Manufacturing labs , 55 pascals + positive pressurisation.

Unidirectional airflow, so no turbulence occurs.

HEPA filters to be used at 99.97% & down to 0.3 microns.

When de-fumigation is done, 100% Fresh air and the equivalent exhaust air to clear the formaldehyde.

Minimum of 20 ACH (air change per hour).

Recirculating air due to the high volume of air from the ACH.

AHU sections but not limited to: Pre-filters, Pre Heat coil, cooling coil, fan, humidifier, air monitoring, reheat coil, return fan, , relief damper, return damper, Fresh air damper,

BMS , DDC system to monitor, all ahu parameters, pressurisation, filters, etc...

For more details please contact the publisher

I can be consulted on this and help you achieve your goals Remotely.

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