Journal Review in Thoracic Surgery: Adjuvant Treatment in Esophageal and GEJ Cancer

In this episode, our team discusses the Checkmate 577 trial, the landmark paper which approved the use of nivolumab for adjuvant treatment of stage II & III esophageal & GE junction cancer. Listen as our team reviews the study population, methods and results of this trial & discusses its clinical application as well as potential areas of future research.

Learning Objectives:

-Review the staging and treatment of esophageal and GEJ cancer

-Discuss the population, methods, and results of the Checkmate 577 trial

-Understand the mechanism of action of nivolumab and the PD1 pathway

-Discuss the implications of the Checkmate 577 trial in clinical practice and areas of future research

Hosts:

Kelly Daus MD, Megan Lenihan MD, Peter White MD, and Brian Louie MD

Referenced Material

https://www.nejm.org/doi/full/10.1056/NEJMoa2032125

Kelly RJ, Ajani JA, Kuzdzal J, et al. Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med. 2021;384(13):1191-1203. doi:10.1056/NEJMoa2032125

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136921/

Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer. Am J Cancer Res. 2020 Mar 1;10(3):727-742. PMID: 32266087; PMCID: PMC7136921.

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If you liked this episode, check out other thoracic surgery episodes here https://behindtheknife.org/podcast-category/cardiothoracic/