On this episode, I discuss leflunomide pharmacology. It is classified as a DMARD and is primarily used in rheumatoid arthritis.



Leflunomide carries a boxed warning for hepatoxicity. LFTs must be monitored with its use. 



Leflunomide can inhibit CYP2C8 which plays an important role in pioglitazone metabolism. Concentrations of pioglitazone can go up on account of this interaction. 



TB screening should be done prior to beginning the immunosuppressant leflunomide.

Leflunomide Pharmacology

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Today’s sponsor of the Top 10 Anticoagulant Drug Interactions podcast is FreedAI. Freed listens, transcribes, and writes medical documentation for you.



FreedAI is offering a discount exclusive to RLP listeners! Users will get $50 off their first month with Freed! Use the discount code: RLPPOD



Apixaban is one of the most commonly used anticoagulants and there are some drug interactions you need to be aware of. Take a listen and find out!



Warfarin concentrations can substantially be elevated by drugs that inhibit CYP2C9. I cover a few of them in my top 10 anticoagulant drug interactions.

Top 10 Anticoagulant Drug Interactions

Today's sponsor of the Top 10 SSRI Drug Interactions podcast is FreedAI. Freed listens, transcribes, and writes medical documentation for you.



FreedAI is offering a discount exclusive to RLP listeners! Users will get $50 off their first month with Freed! Use the discount code: RLPPOD



In this podcast episode, I discuss how to navigate SSRI drug interactions and identify some of the most common medications that have additive serotonergic activity. 



SSRIs have antiplatelet activity. I discuss how to navigate using other medications that may increase bleed risk in combination with SSRIs. 



Paroxetine and fluoxetine inhibit CYP2D6 I discuss how this can affect the benefits of tamoxifen therapy. 



Fluvoxamine is a nasty medication with regard to the number of and significance of drug interactions. I outline important fluvoxamine interactions in this podcast episode.

Top 10 SSRI Drug Interactions Podcast

On this episode, I discuss travoprost pharmacology, adverse effects, administration, and much more on this podcast episode. 



Travoprost is used to reduce intraocular pressure in the management of glaucoma. I discuss the mechanism of action and adverse effects. 



Travoprost is a prostaglandin analog that can help reduce intraocular pressure and reduce the risk of the potential complication of blindness. 



Growth of eyelashes is a unique adverse effect associated with travoprost.

Travoprost Pharmacology

On this podcast episode, I finish up my breakdown of the Beers Criteria. 



I cover the use of sliding-scale insulin and sulfonylureas in geriatric patients. Hypoglycemia is a major concern with both of these diabetes management strategies. 



PPIs show up on the Beers criteria list as they can increase the risk of C. diff, pneumonia, fractures, and GI malignancies. 



Metoclopramide has dopamine antagonist activity and can increase the risk of EPS and tardive dyskinesia.

Beers Criteria Podcast Part 2 or 2

In this podcast episode, I break down some of the most common medications that show up on the Beers criteria list. 



I discuss cardiovascular medications in this podcast episode, including rivaroxaban and warfarin, and why they show up on the Beers list. 



Alpha-blockers who up on the Beers list as these medications are inappropriate to use for the management of hypertension. 



The Beers criteria addresses the use of aspirin in primary prevention. I break down what the criteria state and why it should be avoided in general.

Leflunomide Pharmacology

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