In this podcast, Dr. Valentin Fuster discusses a groundbreaking study published in JACC that examines the impact of the POET trial on the treatment of infective endocarditis. The study found that transitioning to oral antibiotic therapy after just 10 days of intravenous treatment reduced hospital stays by 8 days, without increasing mortality, and lowered relapse rates of bacteremia, suggesting a major shift toward oral antibiotics as a viable alternative to prolonged intravenous therapy.