The San Francisco 49ers pulled off a massive upset over the Los Angeles Rams with seemingly their entire group of skill position players missing the game other than Christian McCaffery. Mac Jones was nails all night and made all the right move to get a big-time win and take the NFC West division lead. The Kansas City Chiefs head to Jacksonville to take on the Jaguars in a game that pits two of the AFC's best records and while the Chiefs have more benefit of the doubt, this Jaguars team will make it tough on them and should cover the 3 points. The Buffalo Bills host the New England Patriots and this is a perfect spot for Mike Vrabel's team to make it closer than people expect. After getting upset by the New York Giants, the Los Angeles Chargers come home and will roll against the Washington Commanders, even if Jayden Daniels is back. Staying out west, the Arizona Cardinals are set for a big win over the Tennessee Titans. Finally, the Indianapolis Colts will keep on rolling against the Las Vegas Raiders as they are a far more talented team.

 

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