The Mysterious Traveler featured shows ranging from science fiction, fantasy, horror, to crime drama. The Mysterious Traveler scripts totaled over 400 with only about 100 surviving today.

"This is the Mysterious Traveler, inviting you to join me on another journey into the strange and terrifying. I hope you will enjoy the trip, that it will thrill you a little and chill you a little. So settle back, get a good grip on your nerves and be comfortable—if you can!"

That introduction, accompanied by the now famous sound of the rushing train and its whistle served as the chilling prologue to every episode of the run.