Nathan Isles was a member of the Seattle Seahawks practice squad in 2014 following his collegiate career at North Carolina A&T. That season, the Seahawks made the Super Bowl. Isles went on to spend time in the CFL before joining the NAL in 2017 with the Columbus Lions, appearing in the NAL Championship. Last season, Isles played for the Columbus Destroyers (AFL) where he played next to fellow Flight signing Donell Andrews.