Paroxetine (Paxil) is an SSRI that can be used in the management of depression. I discuss more on paroxetine pharmacology in this episode.



Because paroxetine has some modest anticholinergic effects, it does show up on the Beers list as a potentially inappropriate medication.



By inhibiting CYP2D6, paroxetine can have numerous drug interactions. Drugs like atomoxetine, aripiprazole, and metoclopramide can all have their concentrations increased.



Tamoxifen is activated by CYP2D6 and paroxetine can ultimately reduce the effectiveness of the medication.

Paroxetine Pharmacology

Education

Training

Language Courses

Higher Education

K-12

Educational Technology

Medicine

Science & Medicine

Health & Fitness

Today's sponsor of the Top 10 SSRI Drug Interactions podcast is FreedAI. Freed listens, transcribes, and writes medical documentation for you.



In this podcast episode, I discuss how to navigate SSRI drug interactions and identify some of the most common medications that have additive serotonergic activity. 



SSRIs have antiplatelet activity. I discuss how to navigate using other medications that may increase bleed risk in combination with SSRIs. 



Paroxetine and fluoxetine inhibit CYP2D6 I discuss how this can affect the benefits of tamoxifen therapy. 



Fluvoxamine is a nasty medication with regard to the number of and significance of drug interactions. I outline important fluvoxamine interactions in this podcast episode.

Top 10 SSRI Drug Interactions Podcast

On this episode, I discuss travoprost pharmacology, adverse effects, administration, and much more on this podcast episode. 



Travoprost is used to reduce intraocular pressure in the management of glaucoma. I discuss the mechanism of action and adverse effects. 



Travoprost is a prostaglandin analog that can help reduce intraocular pressure and reduce the risk of the potential complication of blindness. 



Growth of eyelashes is a unique adverse effect associated with travoprost.

Travoprost Pharmacology

On this podcast episode, I finish up my breakdown of the Beers Criteria. 



I cover the use of sliding-scale insulin and sulfonylureas in geriatric patients. Hypoglycemia is a major concern with both of these diabetes management strategies. 



PPIs show up on the Beers criteria list as they can increase the risk of C. diff, pneumonia, fractures, and GI malignancies. 



Metoclopramide has dopamine antagonist activity and can increase the risk of EPS and tardive dyskinesia.

Beers Criteria Podcast Part 2 or 2

In this podcast episode, I break down some of the most common medications that show up on the Beers criteria list. 



I discuss cardiovascular medications in this podcast episode, including rivaroxaban and warfarin, and why they show up on the Beers list. 



Alpha-blockers who up on the Beers list as these medications are inappropriate to use for the management of hypertension. 



The Beers criteria addresses the use of aspirin in primary prevention. I break down what the criteria state and why it should be avoided in general.

Beers Criteria Podcast Part 1 or 2

On this episode, I discuss the pharmacology surrounding QTc prolongation and drug interactions. 



I discuss which medications are more likely to cause QTc prolongation and which patient populations we should be more concerned about. 



Antiarrhythmics are a common class of medication that can exacerbate QTc prolongation when used with other interacting medications. 



500 ms is a common value utilized to help identify patients at risk for QTc prolongation and ultimately torsades de pointes.

Paroxetine Pharmacology

Download our free app to listen on your phone