Sam Harris speaks with Roland Griffiths about the current state of research on psychedelics. They discuss the historical prohibition against their use; the clinical and scientific promise of psilocybin, mescaline, LSD, DMT, MDMA, and other compounds; the risks associated with these drugs; the role of “set and setting”; the differences between psychedelics and drugs of abuse; MDMA and neurotoxicity; experiences of unity, sacredness, love, and truth; the long-term consequences of psychedelic experiences; synthetic vs natural drugs; the prospects of devising new psychedelics; microdosing; research on psilocybin and long-term meditators; the experience of encountering other apparent beings; psilocybin treatment of addiction; and other topics. In his Afterword, Sam discusses his experience on a large dose of psilocybin—his first psychedelic experience in 25 years. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.

#177 — Psychedelic Science

Join neuroscientist, philosopher, and five-time New York Times best-selling author Sam Harris as he explores important and controversial questions about the mind, society, current events, moral philosophy, religion, and rationality—with an overarching focus on how a growing understanding of ourselves and the world is changing our sense of how we should live. 

Sam is also the creator of the Waking Up app. Combining Sam’s decades of mindfulness practice, profound wisdom from varied philosophical and contemplative traditions, and a commitment to a secular, scientific worldview, Waking Up is a resource for anyone interested in living a more examined, fulfilling life—and a new operating system for the mind. 

Waking Up offers free subscriptions to anyone who can’t afford one, and donates a minimum of 10% of profits to the most effective charities around the world. To learn more, please go to WakingUp.com.  

Sam Harris received a degree in philosophy from Stanford University and a Ph.D. in neuroscience from UCLA.

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Sam Harris speaks with Cal Newport about our use of information technology and the cult of productivity. They discuss the state of social media, the "academic-in-exile effect," free speech and moderation, the effect of the pandemic on knowledge work, slow productivity, the example of Jane Austen, managing up in an organization, defragmenting one's work life, doing fewer things, reasonable deadlines, trading money for time, finding meaning in a post-scarcity world, the anti-work movement, the effects of artificial intelligence on knowledge work, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

#363 — Knowledge Work

Sam Harris and Josh Szeps (episode co-host) speak with Douglas Murray about the ongoing war in Gaza. They discuss public opinion about the war, the prospect of a widening conflict with Hezbollah and Iran, whether the Iron Dome was a mistake, the sentiments of Israeli Arabs, the global problem of Islamism, the risk of a resurgent right-wing in Europe, the crisis at the southern border in the US, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.  Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

#362 — Six Months of War

Sam Harris speaks with William MacAskill about the implosion of FTX and the effect that it has had on the Effective Altruism movement. They discuss the logic of “earning to give,” the mind of SBF, his philanthropy, the character of the EA community, potential problems with focusing on long-term outcomes, AI risk, the effects of the FTX collapse on Will personally, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe.   Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

#361 — Sam Bankman-Fried & Effective Altruism

Sam Harris speaks with Robert Sapolsky about the widespread belief in free will. They discuss the limits of intuition, the views of Dan Dennett, complexity and emergence, downward causation, abstraction, epigenetics, predictability, fatalism, Benjamin Libet, the primacy of luck, historical change in attitudes about free will, implications for ethics and criminal justice, the psychological satisfaction of punishing bad people, understanding evil, punishment and reward as tools, meritocracy, the consequences of physical beauty, the logic of reasoning, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

#360 — We Really Don’t Have Free Will?

Sam Harris speaks with Cass Sunstein about habituation and its consequences. They discuss habituation to positive and negative experiences, marriage, happiness, meaning, variety, doing good vs feeling good, midlife crises, kids, wealth and happiness, things vs experience, the “illusory truth effect,” misinformation and social media, echo chambers and extremism, what governments can do to respond to misinformation, free speech on college campuses, the 2024 Presidential election, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe. Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.

#177 — Psychedelic Science

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