Psychopharmacology and Psychiatry Updates

By Psychopharmacology Institute

Science & Medicine Medicine

What's Psychopharmacology and Psychiatry Updates about?

Practical psychopharmacology updates for mental health clinicians. Useful for psychiatry / mental health professionals. Expert interviews and soundbites from CME presentations. Practical and free of commercial bias. Not sponsored by any pharmaceutical company.

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Melatonin's Impact on Suici...

12.03.2023

Can melatonin reduce the risk of suicidality, bodily injuries, falls, and accidents in children and adolescents? In this episode, we explore a study that delves into this question. Discover how sleep disturbances impact young individuals' health, development, cognitive skills, emotional ...

Psychopharmacology and Psychiatry Updates episodes:

12.03.2023 Melatonin's Impact on Suicidality and Accidents in Adolescents Can melatonin reduce the risk of suicidality, bodily injuries, falls, and accidents in children and adolescents? In this episode, we explore a study that delves into this question. Discover how sleep disturbances impact young individuals' health, development, cognitive skills, emotional ...
11.28.2023 Understanding Sleep-Related Eating Disorder (SRED) Do you know what sleep-related eating disorder (SRED) is and how it intertwines sleep and eating pathologically? In this episode, we delve into an in-depth analysis of SRED, elucidating its diagnostic criteria, key characteristics of the diagnosis, and some intriguing ...
11.23.2023 Pimavanserin: A Solution for Psychosis in Parkinson's Disease? This episode explores the controversial role of pimavanserin in treating psychosis in Parkinson's disease. How does it compare with quetiapine or clozapine? Sneak peek: All of these medications are effective, yet none distinctly surpasses the others. Faculty: Jim Phelps, M.D. ...
11.18.2023 Current Approaches to Treating Pediatric Bipolar Disorder Pediatric bipolar disorder treatment has evolved significantly since 2005, moving beyond lithium to several FDA-approved treatments. However, the challenges remain: How do we choose the first-line treatment? How can we mitigate and monitor side effects? In this episode, we discuss ...
11.13.2023 Exploring Pharmacogenomic Testing in MDD Can pharmacogenomic testing improve the selection and dosing of antidepressants in patients with MDD? In this episode, we explore the findings of the PRIME Care trial and discuss the clinical significance of these tests. Faculty: Jim Phelps, M.D. Host: Richard ...
11.08.2023 Broad-Spectrum Micronutrients: A New Frontier in ADHD Treatment In this episode, we discuss the role of broad-spectrum micronutrients (BSMs) in managing symptoms of ADHD. We examine the rationale behind opting for alternative therapies for this condition and dissect the outcomes of an RCT involving BSMs for ADHD. Could ...
11.03.2023 Predicting Nonadherence in ADHD: A Focus on Side Effects Are you aware that a staggering 80% of ADHD patients report at least 1 side effect from their medication? In this episode, we discuss an analysis that seeks to answer an essential question: Can we predict medication nonadherence in adolescents ...
10.29.2023 How Nutrient Metabolism Influences Mental Health Did you know that your genes could affect how your brain processes vital nutrients? In this episode, we delve into fascinating research on micronutrient supplementation for mental disorders, such as ADHD. Discover how our genetic makeup might dictate our nutrient ...
10.24.2023 Antipsychotics and Substance Use: A Fresh Look at Old Drugs Could antipsychotic switching impact substance use in schizophrenia? In this episode, Dr. Jim Phelps explores the impact of antipsychotics on patients with schizophrenia and substance use disorder. He includes insights from national cohorts and clinical cases and delves into the ...
10.19.2023 The Effect of the Mediterranean Diet on Depression Dive into the fascinating world of nutrition's impact on mental health in our latest episode. We explore intriguing studies on the Mediterranean diet's potential to alleviate depressive symptoms. Can a shift in dietary habits truly improve mental health? Faculty: Amelia ...
10.14.2023 Racial Disparities in Pharmacologic Restraints In this episode, we explore a pressing problem in pediatric psychiatry: The disparities in the use of pharmacologic restraints. How can we address these biases in our healthcare system? What role do behavioral interventions play in reducing the need for ...
10.09.2023 Managing Orthostasis in Patients on Clozapine In this episode, we discuss the causes of clozapine-induced orthostasis. Although some patients may develop tolerance, it can limit titration and potentially obstruct patients from reaching the plasma level where they respond well to the medication. There are practical management ...
10.04.2023 Lavender Extract for Anxiety In this episode, we discuss the potential of lavender extract, Silexan, as an alternative treatment for anxiety and insomnia with Dr. Jim Phelps. Is it truly a promising solution free from dependency and withdrawal symptoms or just an effective placebo? ...
09.29.2023 Psychopharmacology Insights: Clozapine and Constipation In this episode, we explore a common yet severe side effect of clozapine: Constipation. Why does this drug cause such drastic changes in colonic transit times, and how can we manage it effectively? Faculty: Jonathan Meyer, M.D. Host: Richard Seeber, ...
09.24.2023 Understanding the Cardiovascular Impact of ADHD Medication In this episode, we discuss a comprehensive study on the potential cardiovascular risks of ADHD medication. Although these medications pose minimal risk for those without preexisting conditions, there seems to be an elevated risk for those with preexisting cardiovascular diseases. ...
09.19.2023 Sialorrhea: A Clozapine Side Effect In this episode, we delve into the problem of sialorrhea or excessive salivation in patients on clozapine. Why does this occur, and how can it be managed? Join us as Dr. Jonathan Meyer shares his expertise on this unique side ...
09.14.2023 Inflammation and Antidepressants: A New Treatment Frontier? Can a simple lab test guide our choice of antidepressants? Explore the intriguing link between inflammation, measured by C-reactive protein (CRP) levels, and the effectiveness of certain antidepressants in this episode. Faculty: Jim Phelps, M.D. Host: Richard Seeber, M.D. Learn ...
09.09.2023 Ketamine Therapy: A New Hope for Adolescent Depression? Could ketamine be the breakthrough we need in treating adolescent depression? Join us in this episode as we explore the potential of ketamine therapy and its rapid antidepressant effects. Also, learn how ketamine works, its safety profile, and why it's ...
09.04.2023 Unraveling Nightmares: Exploring REM Sleep Behavior Disorder In this episode, we dive into the puzzling case of a 67-year-old man experiencing violent moving nightmares. Is it rapid eye movement sleep behavior disorder, frequent and recurring nightmares, night terrors, PTSD, or another parasomnia? Tune in as we explore ...
08.30.2023 Acute Agitation and Dexmedetomidine: A Novel Treatment Approach In this episode, we delve into a new horizon in the management of acute agitation. We discuss dexmedetomidine, a drug that's been around since 1999, recently reformulated into a sublingual film and FDA approved for treating agitation associated with schizophrenia ...
08.25.2023 The Prevalence and Risks of RBD In this episode, we dive into rapid eye movement sleep behavior disorder (RBD). Did you know that RBD's prevalence is on par with schizophrenia in middle-aged and older adults? Tune in as we explore the prevalence, assessment, and management of ...
08.20.2023 ADHD Medication and Their Role in Anxiety and Depression In this episode, we dive deep into the effects of ADHD medication on anxiety and depressive symptoms in children and adolescents. Can these medications significantly exacerbate symptoms of anxiety or depression? Or do these symptoms arise more from the underlying ...
08.15.2023 In the Realm of Sleep: RBD Diagnosis Explained In this episode, we delve deep into the diagnostic mysteries of RBD, the need for video polysomnography, and the mechanisms leading to RBD. Whether you are a veteran or new to the field, this episode promises to deepen your understanding ...
08.10.2023 NAC in Schizophrenia: Pie in the Sky or Groundbreaking Solution? Are we missing a vital piece in the schizophrenia treatment puzzle? In this episode, we explore the intriguing and controversial role of N-acetylcysteine (NAC) in schizophrenia. We dive deep into the evidence, the theories, and the ongoing debates about this ...
08.05.2023 Child Psychiatry: NAC and SAMe How can N-acetyl cysteine (NAC) and S-adenosyl methionine (SAMe) be effectively integrated into child and adolescent psychiatric treatment? In this episode, we dive deep into the world of NAC and SAMe and explore their potential applications, dosage, side effects, and ...
07.31.2023 Youth Psychotropic Prescription Trends: Pandemic Influence How has the use of antipsychotics among children and adolescents been affected by the COVID-19 pandemic in the United States? In this episode, we delve into pandemic-induced trends in youth psychotropic prescriptions. Uncover how COVID-19 reshaped mental health services and ...
07.26.2023 Nature's Remedies in Youth: St. John's Wort and Valerian Can nature’s remedies hold the key to mental well-being in our youth? In this episode, we delve into the potential uses and limitations of St. John’s wort and valerian in child and adolescent psychiatry and, most importantly, their evidence in ...
07.21.2023 Exploring Serotonergic Antidepressants for PMDD Have you ever pondered the mystery behind the effectiveness of different SSRI dosing strategies for premenstrual dysphoric disorder (PMDD)? In this episode, we delve deep into the complex world of PMDD treatments, focusing on the intriguing comparison between intermittent luteal ...
07.16.2023 Exploring Omega-3's Role in Child Psychiatry Have you ever wondered how natural remedies like omega-3 fatty acids might influence child and adolescent psychiatry? In this episode, we delve into the intriguing world of omega-3 fatty acids and their potential role in treating various psychiatric disorders in ...
07.11.2023 ADHD Meds for Preschoolers: Lisdexamfetamine Have you ever wondered about the safety and effectiveness of ADHD medications in preschoolers? In this episode, we discuss a pioneering double-blind, fixed-dose study exploring the use of lisdexamfetamine in children aged 4–5 years. We delve into the nuances of ...
07.06.2023 Using Ginkgo Biloba in Children In this episode, we delve into the intriguing world of ginkgo biloba and its potential role in treating ADHD in children and adolescents. Can this ancient herbal remedy offer a valuable alternative or adjunctive therapy? Faculty: David Rosenberg, M.D. Host: ...
07.01.2023 Examining COVID's Lasting Effects in Psychiatry In this episode, we delve into the intriguing world of COVID-19's long-term effects in psychiatry. We explore a groundbreaking study that examines the duration of COVID-associated psychiatric disorders and variations in susceptibility by age. How long do these disorders persist, ...
06.26.2023 Beyond SSRIs: Antipsychotic Augmentation in OCD In this episode, you'll discover the preferred second-generation antipsychotics for augmenting treatment for obsessive-compulsive disorder: Risperidone and aripiprazole. We discuss their effectiveness and important considerations when choosing between them. What factors should clinicians weigh when deciding on an augmentation strategy? ...
06.21.2023 Overcoming Barriers to Metabolic Monitoring in Youth Treated With SGAs In this episode, we focus on the challenges faced in metabolic monitoring of youth receiving second-generation antipsychotics (SGAs), including the strategies to overcome these barriers and ensure the long-term health of young patients on SGAs. Faculty: David Rosenberg, M.D. Host: ...
06.16.2023 Exploring Outcomes and Strategies in OCD Treatment After the First Trial In this episode, we delve into the potential outcomes after the first SSRI trial for OCD. With SSRIs being a first-line treatment, understanding response patterns is crucial. What course of action should be taken when patients exhibit significant symptom improvement, ...
06.11.2023 Diving Into the APA Annual Meeting: Highlights and Insights! In this episode, Dr. Richard Seeber and his special guests, Dr. Lorena Rodriguez and Dr. Paz Badia, discuss the topics covered in the APA Annual Meeting 2023, from technology in mental health practice to the use of cognitive–behavioral therapy for ...
06.06.2023 Exploring the Intriguing World of Microdosing Psilocybin In this episode, we delve into the fascinating world of microdosing psilocybin. A recent randomized trial examined the effects of microdosing using various outcome measures. Surprisingly, the acute effects were significantly more intense for the active dose but only when ...
06.01.2023 SSRIs for OCD: A Closer Look at First-Line Treatment What factors should clinicians consider when choosing an SSRI for treating patients with OCD? In this episode, we dive into the first-line treatment for OCD: SSRIs. Discover the most effective SSRIs for treating OCD, recommended doses, and potential adverse effects. ...
05.27.2023 Exploring Nonstimulant Treatments for ADHD Are there any particular situations where nonstimulant medications may be especially effective for ADHD? In this episode, we discuss nonstimulant treatments for ADHD. Although stimulants are commonly used for ADHD, nonstimulant options like atomoxetine, viloxazine, clonidine, and guanfacine have been ...
05.22.2023 Complexities of OCD Treatment: Comorbidities and Other Considerations In this episode, we share insights into the comorbidities and other considerations that can impact the treatment algorithm for OCD. From the risks of medication use in pregnant women, to the challenges of treating OCD in patients with comorbid bipolar ...
05.17.2023 Lamotrigine and Lithium Combination Therapy for Rapid Cycling Bipolar Disorder In this episode, we discuss rapid cycling bipolar disorder and its treatment, focusing on the use of the combination of lamotrigine and lithium. We also highlight the importance of checking thyroid status and tapering antidepressants in patients with rapid cycling. ...
05.12.2023 Melatonin and Secretin for Youth In this episode, we discuss the potential use of melatonin as a safe and effective pharmacotherapy for sleep disturbances in children with ADHD and ASD. Did you know that up to 80% of children with ASD experience sleep disorders? Listen ...
05.07.2023 Tackling NSSI in Adolescents: Can Medications Help? Which medications are safe and effective for treating nonsuicidal self-injury (NSSI) in children and adolescents? In this episode, we discuss the use of psychotropic medications in treating NSSI, which is becoming increasingly common in this population and can predict future ...
05.02.2023 D-Cycloserine for Anxiety Disorders in Youth This episode discusses D-cycloserine’s potential indications and administration in children and adolescents, including the evidence for anxiety disorders, OCD, ASD, and PTSD. It also mentions the dosage, administration, benefits, and side effects of D-cycloserine in youth. Faculty: David Rosenberg, M.D. ...
04.27.2023 Clinical Significance of Antidepressants for the Treatment of Acute Depression Antidepressants are commonly used to treat depression, but how effective are they? In this episode, we discuss the concept of the minimal clinically important difference (MCID) and how it can be applied to assess antidepressant efficacy in treating depression. Specifically, ...
04.22.2023 Memantine: Potential Indications in Youth What is the role of memantine in pediatric populations? This episode discusses memantine’s potential indications and administration in children and adolescents, an explanation of the theory of glutamatergic dysregulation, and the evidence of memantine for ASD, OCD, and mood disorders. ...
04.17.2023 Low-Dose Olanzapine for Anorexia Nervosa In this episode, we examine the tolerability, safety, and effectiveness of low-dose olanzapine in adolescents with anorexia nervosa (AN). Learn about the potential benefits and risks of using olanzapine in AN patients and the importance of a multidisciplinary approach in ...
04.12.2023 Naltrexone in Youth: Exploring Potential Applications and Cautions In this episode, we discuss the potential uses and challenges of naltrexone in children and adolescents while addressing the limited and conflicting evidence. We also examine the dosage, side effects, and important considerations for using naltrexone in young populations. Faculty: ...
04.07.2023 Lamotrigine Titration: Slowing Down for Safer Treatment Would a slower lamotrigine titration rate decrease the likelihood of developing the dreaded lamotrigine-associated rash? This episode discusses the possible advantages of slower lamotrigine titration rates, tips for managing benign rashes, and when to rechallenge lamotrigine. Faculty: Jim Phelps, M.D. ...
04.02.2023 Using Benzodiazepines in Geriatric Patients In this episode, we dive into a topic that's especially relevant for those working with older adults: The use of benzodiazepines and sedative-hypnotics. We explore the unique considerations of prescribing these medications to geriatric patients and the importance of deprescribing ...

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