Psychopharmacology and Psychiatry Updates

By Psychopharmacology Institute

Science & Medicine Medicine

What's Psychopharmacology and Psychiatry Updates about?

Practical psychopharmacology updates for mental health clinicians. Useful for psychiatry / mental health professionals. Expert interviews and soundbites from lectures. Practical and free of commercial bias. Not sponsored by any pharmaceutical company.

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Delirium, Catatonia, and CO...

09.14.2021

This podcast offers a discussion on catatonia and delirium as well as treatments for their co-occurrence. Treatments discussed include benzodiazepines, amantadine, and memantine. We also address the management of COVID-19 delirium with antipsychotics.

Psychopharmacology and Psychiatry Updates episodes:

09.14.2021 Delirium, Catatonia, and COVID-19 This podcast offers a discussion on catatonia and delirium as well as treatments for their co-occurrence. Treatments discussed include benzodiazepines, amantadine, and memantine. We also address the management of COVID-19 delirium with antipsychotics.
09.09.2021 Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder Is psilocybin a potential treatment for major depression? There's certainly been a lot of press coverage, but to date, the reports are largely open trials in a variety of conditions, including OCD, substance use, PTSD, and patients with cancer and ...
09.04.2021 Dopamine and Depression: Clinical Considerations This podcast features a discussion on the need to highlight anhedonia and anergia as core symptoms of depression. We also cover the clinical utility of MAOIs in treating patients with melancholic or biological depression and Parkinson's disease.
08.30.2021 Haloperidol, Chlorpromazine, and Atypical Antipsychotics for Managing Delirium This podcast offers a discussion on the use of antipsychotics for managing delirium. Topics covered include: Choosing an antipsychotic, the advantages of IV haloperidol, different dosing strategies, and concerns regarding QT prolongation. We also examine chlorpromazine, olanzapine, quetiapine, and aripiprazole ...
08.25.2021 New Somatic Treatments for Child and Adolescent Depression First-line treatments for child and adolescent depression are cognitive–behavioral therapy, interpersonal therapy, fluoxetine, and escitalopram. What works besides routine first-line approaches? This episode discusses options to consider: Pharmaceuticals, nutraceuticals, somatomotor techniques (e.g., yoga), and neuromodulatory tools (e.g., ECT and TMS).
08.20.2021 Management of Delirium: Nonpharmacologic Strategies This episode discusses nonpharmacologic management strategies for delirium, such as the ones included in the ABCDE bundle.
08.15.2021 Emerging Complementary and Integrative Therapies for Geriatric Mental Health Are there any alternative medicine treatments that might be useful for your geriatric patients? We examine the evidence base for diet, herbal and nutritional supplements, and mind–body therapies for the prevention of dementia and the treatment of depression.
08.10.2021 Delirium: Assessment, Consequences, and Sequelae This episode discusses the assessment of delirium. This includes: EEG and neurological exam, cognitive dysfunctions present in delirium, recommended testing, differential diagnoses, and the consequences of delirium.
08.05.2021 In Search of a Dose-Response Relationship in SSRIs A meta-analysis of antidepressant doses and responses finds no evidence of improved outcomes with higher doses, just more side effects. However, this conclusion is based on fixed-dose comparison studies, which do not mirror the way we practice. Here we'll compare ...
07.31.2021 Valproate/Divalproex: Metabolism, Kinetics, and Warnings This episode discusses valproate kinetics and sublinear kinetics, valproic acid levels, its absolute contraindications, and what to consider when using the package insert.
07.26.2021 Managing Drug-Induced Movement Disorders A practical discussion on akathisia, extrapyramidal symptoms (EPS), tardive syndromes, and acute dystonia.
07.21.2021 Drug Metabolism: The Importance of Child-Pugh Classification for Staging Hepatic Impairment This episode discusses the Child-Pugh scale to assess hepatic impairment. It also covers the FDA's position on the inclusion of drug metabolism data for various Child-Pugh stages and cirrhosis.
07.16.2021 Impact of Smoking Behavior on Clozapine Blood Levels Clozapine blood levels can be influenced by many factors. These include dose, gender, age, body weight, caffeine, medications, and of course, smoking. How much is the reduction in clozapine levels actually due to cigarette smoking?
07.11.2021 The Child-Pugh Scale in Psychiatry This episode discusses the Child-Pugh Rating Scale and how to interpret it, two clinical cases, and the use of paliperidone and lurasidone in patients with hepatic impairment (Child-Pugh C).
07.06.2021 Managing Neuroleptic Malignant Syndrome: An Evidence-Based Update How should we approach the management of neuroleptic malignant syndrome? What is the role of bromocriptine, dantrolene, and ECT?
07.01.2021 Psychotropics and Hepatic Issues: Nonalcoholic Fatty Liver Disease How important are ALT and AST abnormalities when prescribing psychotropics? Should you adjust dosing in patients with elevated ALT and AST? Does inflammation alter drug kinetics?
06.26.2021 Alzheimer's Disease: Can We Lower the Risk? This meta-analysis is a useful reminder of risk factors to look for in your patients. You can also help them understand the long-term risks of Alzheimer's disease.
06.21.2021 Binge Eating Disorder: Diagnosis and Treatment How can you assess binge eating disorder? Which is the preferred screening instrument? What is the role of SSRIs, TCAs, and duloxetine?
06.16.2021 Unipolar Depression: A Psychopharmacology Algorithm What are the best treatment options for severe depression with melancholic features? Can you augment tricyclics? What is the preferred option for depression with mixed features?
06.11.2021 Bulimia Nervosa: Diagnostic and Treatment Essentials When should you suspect bulimia nervosa? What is the role of antidepressants, topiramate, and ondansetron?
06.06.2021 Primary Insomnia: Zolpidem, Behavioral Therapy and CBT-I What are the best treatment options for primary insomnia? What is the role of behavioral therapy and zolpidem?
06.03.2021 Anorexia Nervosa: Diagnosis and Treatment What diagnostic considerations should we keep in mind with anorexia nervosa? What are the most effective medications? Does zinc depletion play a role?
05.27.2021 Pharmacotherapy for Borderline Personality Disorder What is the role of pharmacotherapy in borderline personality disorder? Is there evidence supporting the use of antidepressants? Which antipsychotic can be helpful? Is lamotrigine effective?
05.22.2021 Food Avoidance: Diagnosis and Treatment of Avoidant/Restrictive Food Intake Disorder (ARFID) What is ARFID (Avoidant/Restrictive Food Intake Disorder)? Are antidepressants helpful? What is the role of adjunctive olanzapine?
05.17.2021 Treating Bipolar Disorder in Later Life: Psychopharm Tips Do you treat older patients with bipolar disorder the same as younger patients? What is the optimal lithium dose? What is the role of second-generation antipsychotics such as quetiapine?
05.12.2021 Bereavement and Terminal Illness in Later-Life Depression How to assess prolonged grief? Is there a specific therapy? Is there a role for methylphenidate?
05.07.2021 Anorexia Nervosa and Cardiac Abnormalities Four different changes in cardiac function are associated with anorexia nervosa. All of them generally resolve if weight restoration can be achieved.
05.02.2021 Pharmacotherapy of Depression in Later Lafe: Maintenance Treatment Can you combine donepezil with antidepressants in later-life depression? What are the benefits? What is the downside?
04.27.2021 Antipsychotics Ranked: Metabolic Side Effects and Mortality Risk In schizophrenia, which antipsychotics cause the most weight gain, cholesterol, or glucose increases? Which antipsychotics cause the least? Although a new study may not change your list much, there are some surprises in this episode.
04.22.2021 An Algorithm for Treating Depression in Older Adults What do you do when your patient does not achieve remission? What are the best augmentation strategies?
04.17.2021 How to Treat Hair Pulling and Skin-Picking Disorders What is the role of N-Acetylcysteine (NAC) for hair-pulling and skin-picking Disorders? Should NAC be used as a first-line treatment?
04.12.2021 Clozapine and Risk of COVID-19 Infection Can clozapine increase the risk of COVID-19 infection? What is the role of hypersalivation?
04.07.2021 How to Treat Body Dysmorphic Disorder What is the role of SSRIs for body dysmorphic disorder? Should you prescribe antipsychotics? What are the most powerful medications for patients with delusional insight?
04.01.2021 Should Psychotherapy Alone Be First-Line For Depression? What's an optimal treatment of depression according to a network meta-analysis? Should psychotherapy alone be a default first option?
03.27.2021 Body Dysmorphic Disorder: Tips for Diagnosis What are the clinical features of body dysmorphic disorder? How can you body dysmorphic disorder? Tips for screening.
03.19.2021 Oral Contraceptives in Psychiatry: Potential Effects You Should Know Oral contraceptives can have an impact on mood in women with a history of depression. Can they also mimic the effects of chronic psychological stress?
03.14.2021 Hoarding Disorder: Tips for Diagnosis What are the clinical features of hoarding disorder? How can you assess hoarding disorder? Tips for screening. What other comorbidities should you consider?
03.09.2021 Are Long-Acting Injectable Antipsychotics Better Than Orals? Are long-acting injectable antipsychotics better than oral antipsychotics for preventing relapse and re-hospitalization in schizophrenia?
03.04.2021 Antiepileptics in Pregnancy How bad are valproic acid effects in the newborn? Is there a role for carbamazepine and oxcarbazepine? How to prescribe lamotrigine during pregnancy?
02.27.2021 tDCS for Schizophrenia Is transcranial direct current stimulation for negative symptoms of schizophrenia a good idea?
02.22.2021 Antipsychotics in Pregnancy: Are They Safe? How safe are first-generation antipsychotics in pregnancy? What's their teratogenicity risk? How safe are second-generation antipsychotics? Are risks dose-dependent? What glucose test should you order and when?
02.17.2021 Should you prescribe omega-3 fatty acids? Omega-3 fatty acids have been shown in some randomized trials to be more effective than placebo in the treatment of depression, but a Cochrane review concluded that they are no better than placebo. Should you suggest omega-3 fatty acids for ...
02.12.2021 Prescribing Lithium During Pregnancy How does pregnancy affect lithium pharmacokinetics? How do lithium levels fluctuate across the first, second, and third trimesters? How often should you monitor lithium blood levels? Should you stop lithium prior to labor?
02.07.2021 Using E-Cigarettes: What Clinicians Must Know Can e-cigarettes help in smoking cessation? What are the main disadvantages of e-cigarettes? What is a dual user?
02.02.2021 Premenstrual Mood Syndromes: Oral Contraceptives in Psychiatry? Should psychiatrists prescribe oral contraceptives? What is the role of oral contraceptives in the treatment of PMDD? How do oral contraceptives work in premenstrual syndromes?
01.28.2021 Antidepressants for Bipolar Depression What can we conclude from 9 international guidelines addressing the role of antidepressants in the treatment of bipolar depression? Can antidepressants induce treatment resistance? Some authoritative authors say, maybe.
01.23.2021 PMS and PMDD: Intermittent Antidepressant Dosing? Which antidepressant class is effective for the premenstrual syndromes PMS and PMDD? How can you use antidepressants intermittently to relieve PMS symptoms (luteal-phase and symptom-onset dosing)? Should you prescribe only antidepressants that have been approved by the FDA for PMDD?
01.18.2021 Atomoxetine for Adult ADHD Its most common and not-so-common side effects. What other non-stimulants you can use.
01.13.2021 Premenstrual Mood Syndromes: How to Assess? What is the most helpful and accurate way of understanding premenstrual mood symptoms? What is the preferred scale available? Does it have any limitations? Are period tracking apps useful for diagnosing PMDD?
01.08.2021 Adult ADHD: Using Psychostimulans What is preferred: Long-acting or short-acting formulations? What are the general prescribing principles for all psychostimulants? What are their most common side effects? What side effects you should monitor?

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