There are far too many diseases that do not have proven means of prevention or effective treatments. As such, health care providers must gain better insights into the biology of these diseases to make a difference for the millions of patients who suffer from them. Precision medicine is an emerging approach for treatment and prevention that accounts for individual variability in genes, environment, and lifestyle. Host Frank Russomano welcomes Brian Wells, Associate Vice President of Health Technology and Academic Computing at Penn Medicine, to discuss how Penn Medicine contributes to the precision medicine initiative, from technological developments to supportive infrastructures.