The Proof with Simon Hill

The Surgeon Defending Statins, GLP-1s, and Ancel Keys | Dr Terry Simpson


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In this episode, I sit down with bariatric surgeon and science communicator Dr Terry Simpson for a wide-ranging conversation about health misinformation, GLP-1 medications, statins, ApoB, the Mediterranean diet, and the loud contrarians who dominate social media. Terry has familial hypercholesterolemia, a family history of premature cardiovascular disease, and lost 50 pounds on tirzepatide, all of which give him unusual personal stakes in these debates.

What we cover:

  • How to think about uncertainty in science, and Terry's heuristic for spotting misinformation
  • The Gila monster origin story of GLP-1 medications, and the difference between native and pharmacological GLP-1
  • What food noise actually is, and Terry's own experience on tirzepatide
  • His personal case for statins, an LDL of 190 brought into the 40s, and an ApoB in the 40s
  • A defence of Ancel Keys and the Mediterranean diet
  • Where the carnivore, anti-statin, seed oil, and nattokinase narratives fall apart
  • Compounded GLP-1s, peptide deregulation, and why the FDA still matters
  • If you find this episode useful, please leave a rating and review on Apple Podcasts or Spotify and share it with someone who might benefit.

    To connect with Dr Terry Simpson, visit terrysimpson.com, find him on TikTok at @drterrysimpson, Instagram at @drterrysimpsonmd, X at @drterrysimpson, and Substack at @drsimpson. His podcast is The Unfiltered MD.

    • Intro (00:00)
    • Why Carnivore and Anti-Vax Are Today's Biggest Health Lies (01:02)
    • Doctors, COVID and the Cost of Speaking Up Online (03:58)
    • How to Spot a Health Huckster (13:25)
    • Will GLP-1 Drugs Make Bariatric Surgery Obsolete (19:12)
    • A Bariatric Surgeon's Personal Decision to Take a GLP-1 Drug (22:54)
    • Willpower Is Not the Problem: What Food Noise Actually Feels Like (26:23)
    • Why Ancel Keys Was Right and Low Carb Got It Wrong (32:51)
    • Mediterranean Diet Results That Stopped a Trial Early (39:50)
    • Are GLP-1 Drugs the Greatest Medical Breakthrough This Century (47:38)
    • The Real Danger of Buying Compounded GLP-1 Drugs Online (51:27)
    • BPC-157 and Peptides: Why FDA Guardrails Actually Matter (59:42)
    • Familial Hypercholesterolemia, Statins and a Personal Wake Up Call (01:04:69)
    • Inflammation vs. ApoB: What Actually Causes a Heart Attack (01:13:04)
    • CT Angiogram Results and Keto CTA Data Explained (01:16:33)
    • Fish Oil vs. Eating Fish: Why the Supplement Doesn't Replicate the Food (01:24:35)
    • Simon's Plant Based Diet, Seed Oils and Cooking with Olive Oil (01:28:07)
    • The Seed Oil Debate: Are People Just Afraid of Modern Chemistry (01:33:17)
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      Simon Hill, MSc, BSc (Hons)

      • Creator of theproof.com
      • Host of The Proof with Simon Hill
      • Author of The Proof is in the Plants
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