By Vincent Racaniello
A podcast about the nervous system.
TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode ...
TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Activation of endogenous...
TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS...
TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links...
TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the...
TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV...
TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links...
TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Click arrow to play...
Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison...
Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby...
Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu Subscribe (free): Apple...
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A. Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord...
TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this...
TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this...
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. Hosts: Jason Shepherd and Timothy Cheung Subscribe (free): Apple...
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Microglia...
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, and Timothy Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Meningeal lymph...
TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together. Hosts: Ori Lieberman, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode...
TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode CCR5 and...
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung,...
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiN! Links for this...
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison Click arrow to play Download TWiN 028 (77 MB .mp3, 64 min) Subscribe (free): Apple...
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex. Hosts: Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): Apple...
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Become a patron of TWiN! Links for this episode Memory of immunity (Cell) Timestamps by Jolene. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to...
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival. Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for...
Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin. Hosts: Vincent Racaniello and Timothy...
Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained...
TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links...
TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: Vincent Racaniello, Ori Lieberman, and Timothy Cheung Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN!...
While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung,...
On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function. Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and...
Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. Hosts: Vincent Racaniello, Ori Lieberman, Jason Shepherd, Timothy Cheung, and Vivianne Morrison Guest:...
Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin. Hosts: Vincent...
Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators. Hosts: Ori Lieberman, Jason Shepherd, and Timothy Cheung Guest: Stefano Brigidi Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Genomic...
Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, and Vincent Racaniello Guest: Helen Vuong Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this...
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation. Hosts:...
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello...
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell. Hosts: Ori Lieberman, Vincent Racaniello, and Jason Shepherd Subscribe (free): iTunes, Google...
Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron. Hosts: Ori Lieberman, Andres Bendesky, and Vincent Racaniello Guest: Maria Tosches Subscribe (free): iTunes, Google Podcasts, RSS, email...
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation. Hosts: Ori Lieberman, Andres Bendesky, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links...
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd and Vincent Racaniello Guest: Genna Waldman Subscribe (free): iTunes, Google...
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email...
The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses. Hosts: Ori Lieberman, Jason Shepherd, Erin Calipari and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for the episode The hair...
Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes. Hosts: Ori Lieberman, Andres Bendesky, andJason Shepherd Guest: Nirao Shah Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for...
Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19. Hosts: Ori Lieberman, Andres Bendesky, Jason Shepherd, Erin Calipari and Vincent Racaniello...
Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons. Hosts: Andres Bendesky, Jason Shepherd, and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiN! Links for this episode Arc is...
Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction. Hosts: Ori Lieberman, Erin Calipari,Jason Shepherd, and Vincent Racaniello Click arrow to play...
The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing. Hosts: Ori Lieberman, Andres Bendesky,Jason Shepherd, and Vincent...
The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast. Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd, and Vincent Racaniello Become a patron of TWiN! Links for this episode Lieberman lab Calipari lab Shepherd...
