The Platelet Inhibition and Patient Outcomes (PLATO) trial showed that ticagrelor had better outcomes than clopidogrel for avoiding thrombotic complications following acute coronary syndrome. Subsequent trials suggested that the outcomes for the drugs were about the same. The effects of ticagrelor and clopidogrel were examined in a very large observational study performed by Harlan Krumholz, MD, and colleagues, published in the October 27, 2020, issue of JAMA. Dr Krumholz explains how his study was performed and what it showed. Related Article:  Association of Ticagrelor vs Clopidogrel With Net Adverse Clinical Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention ohdsi.org

Ticagrelor or Clopidogrel for Antiplatelet Therapy After Percutaneous Intervention for Acute Coronary Syndrome?

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Interstitial lung disease (ILD), characterized by inflammation and fibrosis of the lungs, is associated with progressive dyspnea and results in approximately 25 000 to 30 000 deaths in the US each year. Toby M. Maher, MD, MSc, PhD, of Keck Medicine of USC, discusses the diagnosis and management of ILD with JAMA Deputy Editor Mary McGrae McDermott, MD.  Related Content:  Interstitial Lung Disease 

Diagnosis and Treatment of Interstitial Lung Disease

Dislocated hips in newborns can lead to complex surgery, interruption to family life, and premature osteoarthritis. Daniel Perry, MBChb(Hons), PhD, of Alder Hey Children's Hospital, University of Liverpool, discusses the clinical diagnosis of dislocated hips in newborns with JAMA Associate Editor David Simel, MD, MHS.  Related Content:  Does This Infant Have a Dislocated Hip? 

Clinical Diagnosis of Dislocated Hips in Newborns

Systemic lupus erythematosus (SLE) can present at any age and is associated with immune-mediated damage to multiple organs and increased rates of cardiovascular disease, cancer, and disability. New treatments have been FDA approved. Caroline H. Siegel, MD, MS, discusses this and more with JAMA Deputy Editor Mary McGrae McDermott, MD.  Related Content:  Systemic Lupus Erythematosus 

Diagnosis and Treatment of Systemic Lupus Erythematosus

Falls are common in adults older than 65 years and can cause substantial morbidity and mortality. JAMA Associate Editor David Simel, MD, MHS, discusses risk assessment and prevention of falls in older adults with Karin E. Ouchida, MD, of Weill-Cornell Medical University, and author Cathleen Colon-Emeric, MD, of Duke University.  Related Content:  Risk Assessment and Prevention of Falls in Older Community-Dwelling Adults Falls Prevention for Older Adults 

Falls in Community-Dwelling Older Adults

Dry mouth, oral candidiasis, and recurrent aphthous ulcers are common oral conditions that may be associated with patient discomfort, decreased quality of life, and in some cases, morbidity. Author Eric T. Stoopler, DMD, of Penn Dental Medicine, discusses these 3 common oral conditions with JAMA Associate Editor David L. Simel, MD, MHS.  Related Content:  Common Oral Conditions 

Ticagrelor or Clopidogrel for Antiplatelet Therapy After Percutaneous Intervention for Acute Coronary Syndrome?

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