One of the hottest areas in data science and machine learning right now is healthcare: the size of the healthcare industry, the amount of data it generates, and the myriad improvements possible in the healthcare system lay the groundwork for compelling, innovative new data initiatives. One spot that drives much of the cost of medicine is the riskiness of developing new drugs: drug trials can cost hundreds of millions of dollars to run and, especially given that numerous medicines end up failing to get approval from the FDA, pharmaceutical companies want to have as much insight as possible about whether a drug is more or less likely to make it through clinical trials and on to approval. Professor Andrew Lo and collaborators at MIT Sloan School of Management is taking a look at this prediction task using machine learning, and has an article in the Harvard Data Science Review showing what they were able to find. It’s a fascinating example of how data science can be used to address business needs in creative but very targeted and effective ways.

Relevant links:
https://hdsr.mitpress.mit.edu/pub/ct67j043

Using machine learning to predict drug approvals

Linear Digressions is a podcast about machine learning and data science.  Machine learning is being used to solve a ton of interesting problems, and to accomplish goals that were out of reach even a few short years ago.

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All good things must come to an end, including this podcast. This is the last episode we plan to release, and it doesn’t cover data science—it’s mostly reminiscing, thanking our wonderful audience (that’s you!), and marveling at how this thing that started out as a side project grew into a huge part of our lives for over 5 years.

It’s been a ride, and a real pleasure and privilege to talk to you each week. Thanks, best wishes, and good night!

—Katie and Ben

So long, and thanks for all the fish

The data science and artificial intelligence community has made amazing strides in the past few years to algorithmically automate portions of the healthcare process. This episode looks at two computer vision algorithms, one that diagnoses diabetic retinopathy and another that classifies liver cancer, and asks the question—are patients now getting better care, and achieving better outcomes, with these algorithms in the mix? The answer isn’t no, exactly, but it’s not a resounding yes, because these algorithms interact with a very complex system (the healthcare system) and other shortcomings of that system are proving hard to automate away. Getting a faster diagnosis from an image might not be an improvement if the image is now harder to capture (because of strict data quality requirements associated with the algorithm that wouldn’t stop a human doing the same job). Likewise, an algorithm getting a prediction mostly correct might not be an overall benefit if it introduces more dramatic failures when the prediction happens to be wrong. For every data scientist whose work is deployed into some kind of product, and is being used to solve real-world problems, these papers underscore how important and difficult it is to consider all the context around those problems.

A Reality Check on AI-Driven Medical Assistants

A few weeks ago, we put out a call for data scientists interested in issues of race and racism, or people studying how those topics can be studied with data science methods, should get in touch to come talk to our audience about their work. This week we’re excited to bring on Todd Hendricks, Bay Area data scientist and a volunteer who reached out to tell us about his studies with the Stanford Open Policing dataset.

A Data Science Take on Open Policing Data

This is a re-release of an episode that originally ran in October 2019.

If you’re trying to manage a project that serves up analytics data for a few very distinct uses, you’d be wise to consider having custom solutions for each use case that are optimized for the needs and constraints of that use cases. You also wouldn’t be YouTube, which found themselves with this problem (gigantic data needs and several very different use cases of what they needed to do with that data) and went a different way: they built one analytics data system to serve them all. Procella, the system they built, is the topic of our episode today: by deconstructing the system, we dig into the four motivating uses of this system, the complexity they had to introduce to service all four uses simultaneously, and the impressive engineering that has to go into building something that “just works.”

Procella: YouTube's super-system for analytics data storage

Open source software is ubiquitous throughout data science, and enables the work of nearly every data scientist in some way or another. Open source projects, however, are disproportionately maintained by a small number of individuals, some of whom are institutionally supported, but many of whom do this maintenance on a purely volunteer basis. The health of the data science ecosystem depends on the support of open source projects, on an individual and institutional level.

https://hdsr.mitpress.mit.edu/pub/xsrt4zs2/release/2

Using machine learning to predict drug approvals

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