In this episode:
00:46 A virtual chemical library uncovers potential antidepressants Certain psychedelic drugs are of interest to researchers due to their promising antidepressant effects. To help speed up the discovery of molecules with useful properties, researchers have built a virtual library of 75 million compounds related to these drugs. This approach yielded two molecules that showed antidepressant properties in mice, but without the hallucinogenic activity of psychedelic drugs.
Research article: Kaplan et al. Research Briefing: Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
08:25 Research Highlights Research suggests that ancient artificial island settlements were hubs of activity for society’s elite, and astronomers spot possibly the most luminous star ever observed.
Research Highlight: Ancient DNA suggests that artificial islands were party spots for the elite Research Highlight: Scientists face down ‘Godzilla’, the most luminous star known
10:42 Nobel News Flora Graham from the Nature Briefing joins us to talk about the winners of this year’s Nobel Prizes.
Nature News: Geneticist who unmasked lives of ancient humans wins medicine Nobel Nature News: ‘Spooky’ quantum-entanglement experiments win physics Nobel Nature News: Chemists who invented revolutionary 'click' reactions win Nobel
Enter Nature’s ‘Scientist at Work’ photo competition, full details here
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Virtual library of LSD-like drugs could reveal new antidepressants

The Nature Podcast brings you the best stories from the world of science each week. We cover everything from astronomy to zoology, highlighting the most exciting research from each issue of the Nature journal. We meet the scientists behind the results and provide in-depth analysis from Nature's journalists and editors. Hosted on Acast. See acast.com/privacy for more information.

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In this episode:
00:46 Mapping ‘ghost roads’ in tropical forestsAcross the world, huge numbers of illegal roads have been cut into forests. However, due to their illicit nature, the exact numbers of these roads and their impacts on ecosystems is poorly understood. To address this, researchers have undertaken a huge mapping exercise across the tropical Asia-Pacific region. Their findings reveal over a million kilometers of roads that don’t appear on official maps, and that their construction is a key driver for deforestation.
Research Article: Engert et al.
10:44 Research HighlightsHow climate change fuelled a record-breaking hailstorm in Spain, and an unusual technique helps researchers detect a tiny starquake.
Research Highlight: Baseball-sized hail in Spain began with a heatwave at sea Research Highlight: Smallest known starquakes are detected with a subtle shift of colour
13:02 Briefing ChatA clinical trial to test whether ‘mini livers’ can grow in a person’s lymph node, and the proteins that may determine left-handedness.
Nature News: ‘Mini liver’ will grow in person’s own lymph node in bold new trial Nature News: Right- or left-handed? Protein in embryo cells might help decide
Nature video: How would a starfish wear trousers? Science has an answer Vote for us in the Webbys: https://go.nature.com/3TVYHmP
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

The 'ghost roads' driving tropical deforestation

Around the world, rates of cancers that typically affect older adults are increasing in those under 50 years old. Models based on global data predict that the number of early-onset cancer cases like these will increase by around 30% between 2019 and 2030.
The most likely contributors — such as rising rates of obesity and early-cancer screening — do not fully account for the increase. To try and understand the reasons behind this trend, many researchers are searching for answers buried in studies that tracked the lives and health of children born half a century ago.
This is an audio version of our Feature Why are so many young people getting cancer? What the data say Hosted on Acast. See acast.com/privacy for more information.

Audio long read: Why are so many young people getting cancer? What the data say

In this episode: 
00:35 Pregnancy advances your ‘biological’ age — but giving birth turns it backGrowing a baby leads to changes in the distribution of certain chemical markers on a pregnant person’s DNA, but new research suggests that after giving birth, these changes can revert to an earlier state.
Nature News: Pregnancy advances your ‘biological’ age — but giving birth turns it back 
08:07 Bird gestures to say 'after you'A Japanese tit (Parus minor) will flutter its wings to invite their mate to enter the nest first. Use of these sorts of gestures, more complex than simply pointing at an object of interest, were thought to be limited to great apes, suggesting that there are more non-vocal forms of communication to be found in the animal kingdom.
Scientific American: Wild Birds Gesture ‘After You’ to Insist Their Mate Go First 
13:34 The carbon cost of home-grown vegResearch have estimated that the carbon footprint of home-grown food and community gardens is six-times greater than conventional, commercial farms. This finding surprised the authors — keen home-growers themselves — who emphasize that their findings can be used to help make urban efforts (which have worthwhile social benefits) more carbon-efficient.
BBC Future: The complex climate truth about home-grown tomatoes 
20:29 A look at next week's total eclipseOn 8th April, a total eclipse of the Sun is due to trace a path across North America. We look at the experiments taking place and what scientists are hoping to learn. Hosted on Acast. See acast.com/privacy for more information.

Pregnancy's effect on 'biological' age, polite birds, and the carbon cost of home-grown veg

In this episode:01:28 Inflammation’s role in memoryHow memories are stored is an ongoing question in neuroscience. Now researchers have found an inflammatory pathway that responds to DNA damage in neurons has a key role in the persistence of memories. How this pathway helps memories persist is unclear, but the researchers suggest that how the DNA damage is repaired may play a role. As inflammation in the brain is often associated with disease, the team were surprised by this finding, which they hope will help uncover ways to better preserve our memories, especially in the face of neurodegenerative disorders.
Research Article: Jovasevic et al. News and Views: Innate immunity in neurons makes memories persist
08:40 Research HighlightsThe effect of wind turbines on property values, and how waste wood can be used to 3D print new wooden objects.
Research Highlight: A view of wind turbines drives down home values — but only briefly Research Highlight: Squeeze, freeze, bake: how to make 3D-printed wood that mimics the real thing
11:14 How melting ice is affecting global timekeepingDue to variations in the speed of Earth’s rotation, the length of a day is rarely exactly 24 hours. By calculating the strength of the different factors affecting this, a researcher has shown that while Earth’s rotation is overall speeding up, this effect is being tempered by the melting of the polar ice caps. As global time kept by atomic clocks occasionally has to be altered to match Earth’s rotation, human-induced climate change may delay plans to add a negative leap-second to ensure the two align.
Research article: Agnew News and Views: Melting ice solves leap-second problem — for now
20:04 Briefing ChatAn AI for antibody development, and the plans for the upcoming Simons observatory.
Nature News: ‘A landmark moment’: scientists use AI to design antibodies from scratch Nature News: ‘Best view ever’: observatory will map Big Bang’s afterglow in new detail
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday.
Subscribe to Nature Briefing: AI and robotics Hosted on Acast. See acast.com/privacy for more information.

How climate change is affecting global timekeeping

This podcast has been corrected: in a previous version at 5:55 we stated that that the team's 200mm devices currently contain only a couple of magnetic tunnelling junctions, in fact they studied 500-1000 devices in this work. 
00:48 How mysterious skyrmions could power next-generation computersSkyrmions are tiny whirlpools of magnetic spin that some researchers believe have useful properties that could unlock new kinds of computing. However getting skyrmions to perform useful computational tasks has been tricky. Now researchers have developed a method to create and manipulate skyrmions in a way that is compatible with existing computing technology, allowing them to read and write data at a fraction of the energy cost of conventional systems. The team think this shows that skyrmions could be a viable part of the next generation of computers.
Research Article: Chen et al. News and Views: Magnetic whirlpools offer improved data storage
07:51 Research HighlightsHow robotically-enhanced, live jellyfish could make ocean monitoring cheap and easy, and how collective saliva tests could be a cost-effective way of testing for a serious infant infection.
Research Highlight: These cyborg jellyfish could monitor the changing seas Research Highlight: Pooling babies’ saliva helps catch grave infection in newborns
10:01 AI identifies X factor hidden within zebra finch songsMale songbirds often develop elaborate songs to demonstrate their fitness, but many birds only learn a single song and stick with it their entire lives. How female birds judge the fitness between these males has been a long-standing puzzle. Now, using an AI-based system a team has analysed the songs of male zebra finches and shown that some songs have a hidden factor that is imperceptible to humans. Although it’s not clear exactly what this factor is, songs containing it were shown to be harder to learn and more attractive to females. The researchers hope that this AI-based method will allow them to better understand what makes some birdsong more attractive than others.
Research article: Alam et al.  News and Views: Birds convey complex signals in simple songs
20:04 Briefing ChatHow H5N1 avian influenza is threatening penguins on Antarctica, and why farmed snake-meat could be a more environmentally-friendly way to produce protein for food.
Nature News: Bird-flu threat disrupts Antarctic penguin studies Scientific American: Snake Steak Could Be a Climate-Friendly Source of Protein
Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Virtual library of LSD-like drugs could reveal new antidepressants

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