Dr. Will Cole, leading functional-medicine expert, consults people around the world via webcam and locally in Pittsburgh. He specializes in clinically investigating underlying factors of chronic disease and customizing health programs for thyroid issues, autoimmune conditions, hormonal dysfunctions, digestive disorders, and brain problems. Dr. Cole was named one of the top 50 functional-medicine and integrative doctors in the nation and is a health expert and course instructor for the world’s largest wellness brands such as mindbodygreen and goop.   Dr. Cole’s contact information:    www.drwillcole.com Instagram: @drwillcole     Ancestral Supplements https://ancestralsupplements.com/   Code SALADINOMD on the shopify site to receive 10% off.   Use the code CARNIVOREMD at www.whiteoakpastures.com all month for 10% off your order!   JOOVV: www.joovv.com/paul   INSIDER: carnivoremd.com   My contact information:   Book: www.thecarnivorecodebook.com   PATREON:  https://www.patreon.com/paulsaladinomd   SOCIAL MEDIA  Instagram: @carnivoremd Website: carnivoremd.com Twitter:@carnivoremd  Facebook: Paul Saladino MD email: drpaul@carnivoremd.com

26. What the heck causes inflammation and how to correct it with Dr. Will Cole

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

Medicine

Science & Medicine

Health & Fitness

This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results.


00:00:00 Podcast begins
00:01:40 Traditional bloodwork 
00:05:40 MTHFR polymorphism: Does Paul take supplements?
00:10:10 Glucose & creatine
00:14:10 Electrolytes & insulin
00:23:10 Thyroid panel
00:26:18 Cortisol to DHEA sulphate ratio
00:32:20 Cholesterol panel
00:46:10 Hormones & Other results
00:50:20 Iron panel
00:52:40 What bloodwork should you get?




References:
July 2022 Bloodwork: https://www.youtube.com/watch?v=NuD9lWHMup8&t;=669s
August 2022 Bloodwork: https://www.youtube.com/watch?v=1br0cDkYv3Y
December 2022 Bloodwork: https://www.youtube.com/watch?v=LQE3mrwaE8c
March 2023 Bloodwork: https://www.youtube.com/watch?v=vonHW14TTdg




DEXA scan reveals “side effects” of red meat: https://www.youtube.com/shorts/ZgRoz60ugnc


Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://pubmed.ncbi.nlm.nih.gov/20498139/


Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies: https://pubmed.ncbi.nlm.nih.gov/7270479/


Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study: https://pubmed.ncbi.nlm.nih.gov/8077891/


The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study: https://pubmed.ncbi.nlm.nih.gov/22921881/


Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study: https://pubmed.ncbi.nlm.nih.gov/17327867/


Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults: https://www.nature.com/articles/s41598-018-38461-y


Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry: https://pubmed.ncbi.nlm.nih.gov/36621817/


Get your bloodwork from ultalabs.com

249. Bloodwork Review: April 2024

While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality. 


Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt

*Produced by Mountain Valley Media

00:00:00 Podcast begins
00:03:00 The devaluation of food preparation in modern society
00:09:00 how supply chain issues contribute to poor food quality 
00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet
00:28:47 Ads
00:45:21 Why most “grass-finished” beef isn’t what you think it is
01:05:09 Lineage Ad
01:13:21 Paul’s beef with seafood
01:21:20 Testing for PFAs
01:25:17 What to expect from Lineage Provisions 
01:28:45 Answering FAQs about Lineage Provision’s meat sticks

Buy Lineage Beef Sticks: https://lineageprovisions.com/products/classic-meat-sticks

248. Why I Built a Food Company with Anthony Gustin

Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.


*Produced by ⁠Mountain Valley Media


00:00:00 Podcast begins
00:01:23 What is fluoride and is it harmful?
00:07:30 How to filter your water
00:09:00 Western medicine & longevity
00:27:00 Food sourcing and big food
00:30:50 Cyanocobalamin
00:34:55 Folic acid
00:42:00 Gathering objective & subjective data
00:49:00 The importance of gene testing & methylation

247. Gary Brecka: Tap Water is Lowering Your IQ!

On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.


*Produced by ⁠Mountain Valley Media

00:00:00 The importance of heart & riboflavin
00:08:30 Pauls new company: Lineage
00:10:50 Thoughts on creatine
00:19:10 Paul’s experience with white rice & potatoes
00:24:45 Paul experimenting with supplements for methylation

Check out Lineage Meat Sticks: https://lineageprovisions.com/password

References:
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

246. Some things I'm experimenting with lately...

This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.


*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins
00:04:00 Mike’s background
00:05:15 Diving into fructose
00:13:00 Thoughts on honey and other carb sources
00:27:30 Robert Lustig rebuttal: is fructose addictive?
00:37:40 Fructose & fiber
00:47:00 How fructose affects the mitochondria
00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia
00:56:17 Is insulin the bad guy?
01:12:20 How insulin relates to diabetes, obesity, and insulin resistance
01:23:30 Balancing protein, fat and carbohydrates
01:30:00 Is fructose making us fat?
01:46:00 Final thoughts


Connect with Mike:
Mikefave.com
https://m.youtube.com/@MikeFaveSimplified


References:
Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url;_ver=Z39.88-2003&rfr;_id=ori%3Arid%3Acrossref.org

Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/

Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/

Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/

Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/

Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/

Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/

Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/

Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

26. What the heck causes inflammation and how to correct it with Dr. Will Cole

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