One of the greatest sufferings for the human mind is isolation. While physical torture is certainly great suffering, isolation is the greatest spiritual suffering. Penitentiaries will put the harshest criminals in solitary confinement. Secular psychologists argue that being alone will cause great harm to the individual psyche. From a biblical perspective, the psyche is also argued to be the soul. Even the great philosopher Aristotle argued that the psyche [ψυχή] is the soul. Furthermore, English translators of Scripture often translate ‘psyche’ as ‘soul.’ So biblically, we can see that isolation from God the Father is the greatest torment of the soul but can also be a turning point back to God the Father. We can further see Biblically that the soul is life and Jesus’ soul, his very ψυχή was tormented and his body tortured during his Great Suffering and Crucifixion. While Jesus suffered tragedy in his final 24 hours of pain and trial, the greatest suffering that he endured was the temporary separation from the Father. It was this cosmic reality of separation and isolation that was Jesus’ torment more than any other physical pain. Just as the disciples would enter a season of temptation to be sifted like wheat by Satan [Matthew 26:30–35 & Luke 22:31–34], Jesus the Son would be sifted, tortured, falsely tried, and endure the agony of crucifixion. His tormented soul swam in torturous physical abuse while facing the terror of isolation from God the Father. For the Father in Heaven to turn HIS face away from HIS Son was the greatest of all suffering. “Eloi, Eloi, lema sabachthani?! Which means ‘My God, my God, why have you forsaken me?!” [Matt. 27:46 & Mark 15:34] Let’s dig into Matthew 26:36–46 together and glean from our LORD on how to pray in great times of depression, anxiety, agony, and fear