After decades of failed drug trials, two new drugs have emerged in slowing memory loss associated with Alzheimer's disease: Leqembi and Donanemab. In Episode #015 I deep dive into novel Alzheimer's therapies to discuss their effectiveness, safety, and how to find out if you're at risk.

Chapters:

(0:00) Introduction

(2:00) Who's most at risk of Alzheimer's Disease?

(5:52) The Amyloid Hypothesis

(7:14) Leqembi approved by FDA

(9:16) Donanenmab may be next

(12:10) Alzheimer's drugs, brain bleeding, and death

(16:01) How do you know if you have Alzheimer's?

(21:20) Dementia and CTE

(22:49) Do taking smart drugs make us more productive? Is it worth the risk?

(27:00) The Connect - viewers' comments from previous episodes

Show Notes:

Alzheimer’s drug being tested Leqembi or Lecanemab

https://www.abc.net.au/news/2023-07-07/alzheimer-s-disease-drug-leqembi-gets-green-light-in-us/102575974

Donanemab:

https://www.abc.net.au/news/2023-05-04/eli-lilly-drug-alzheimer-cognitive-decline-by-35-per-cent/102301474

Systematic failure of Alzheimer’s drug trials:

https://www.abc.net.au/news/health/2020-02-26/alzheimers-drug-failure-raises-questions-about-research/11996258

Are these drugs safe?

https://www.science.org/content/article/alzheimer-s-trial-shows-clear-benefits-and-significant-risks-eli-lilly-antibody

Symptoms of Alzheimer’s:

https://www.dementia.org.au/about-dementia/types-of-dementia/alzheimers-disease?gclid=Cj0KCQjwzdOlBhCNARIsAPMwjbz46yEPHVQnD-rqxwHOQrtlHnD2gWQdBRIGW9fc-bDlQzjxd2M-TfgaAvMOEALw_wcB

Mini Mental State Examination (MMSE)

https://cgatoolkit.ca/Uploads/ContentDocuments/MMSE.pdf

CTE in female athlete:

https://theconversation.com/australian-researchers-confirm-worlds-first-case-of-dementia-linked-to-repetitive-brain-trauma-in-a-female-athlete-208929

Smart drugs make you dumb:

https://theconversation.com/smart-drugs-make-you-worse-at-solving-complex-problems-new-study-finds-207711

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