We talk to Cardiologist Dr. Jonathan Davis, Director of the Heart Failure program from San Francisco General about goal directed medical therapy in heart failure with reduced ejection fraction (HFrEF). This is part 1 of 2 parts which will cover an overview of GDMT medications, and dive into Beta-blockers and ARNIs. Part 2 to come out next week!

| 00.34 - Introduction |

| 01.55 - Consult Q: GDMT for HF |

• Heart failure outcomes

| 05.20 - GDMT medication summary and overview |

| 07.17 - Effect on blood pressure and relative risk reduction for each drug |

| 10.59 - What order to start in |

• Hint: ALL AT ONCE… if you can

| 11.53 - Beta-blockers |

• When not to start (new HF in VOL), and when to re/start (almost all other times)
• Tartrate vs Succinate: duration of action

| 15.40 - ARNI (Sacubitril-Valsartan) |

• Potent natriuresis effect
• Balancing the orthostatics

| 20.37 - Outro |

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Music by Amit Apte. Medical Heart Vectors by Vecteezy