Every human story begins long before fertilisation itself. In this episode, we explore how gametes are formed, shaped, and prepared for the extraordinary moment when two cells become one developing organism. Rather than treating spermatogenesis and oogenesis as lists of stages, we focus on why errors here echo through a lifetime.

Using Langman’s mechanistic clarity, IB Singh’s structured sequencing, and Moore’s clinical framing, this episode traces fertilisation as both a biological and conceptual threshold — the moment where genetic material, cellular machinery, and developmental timing align. We also examine what happens when alignment fails, from chromosomal abnormalities to infertility.

By the end, fertilisation is no longer a single event to memorise, but a gateway concept that explains why embryology is so sensitive to timing, environment, and precision.

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