Perennially stoned Cheech (Cheech Marin) and Chong (Thomas Chong) tear through the city of Los Angeles, causing trouble wherever they go. After Cheech loses his job, the two pot enthusiasts head to the welfare offices where Cheech's girlfriend, Donna (Evelyn Guerrero), works. Instead of collecting unemployment, they find themselves thrown back on the streets, searching for a way to earn new income. But when Cheech's cousin, "Red" Mendoza (Rikki Marin), arrives, things get even crazier.