Join us in this episode of BioSpeak as we discover the structure and function of the outer cell membrane in Gram-negative bacteria. Learn how this crucial layer differs from the plasma membrane, serving as a protective moat composed of lipopolysaccharides (LPS) that shields the bacterial cell. We willl cover the significance of Lipid A and the O-antigen polysaccharide in immune responses and bacterial adaptability. Discover the role of porins as molecular gatekeepers, allowing nutrient transport, and efflux pumps that expel toxins from the cell. We’ll also discuss the implications of the outer cell membrane for antibiotic development and treatment strategies against Gram-negative bacterial infections.