Ying Lu is an Assistant Professor in the Department of Systems Biology at Harvard Medical School. His work combines physics, biochemistry, and quantitative methods to understand the fundamental mechanisms of biological processes, particularly protein degradation. In this episode, we discuss why curiosity is the most powerful engine for scientific breakthroughs, from the discovery of CRISPR to modern weight-loss drugs. We explore the cell’s sophisticated quality control system, where a "barcode" tag called ubiquitin marks unwanted proteins for destruction by a nanoscale "shredder." Professor Lu explains how failures in this system are linked to diseases like Alzheimer's and cancer, and how his research could lead to new therapies that either inhibit or boost this process to restore health.

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